7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxyprop-1-enyl]-5-oxocyclopentyl]heptanoic acid

Base Information

Chemical Name:7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxyprop-1-enyl]-5-oxocyclopentyl]heptanoic acid
CAS No.:62407-92-5
Molecular Formula:C23H38O4
Molecular Weight:378.5454
Hs Code.:

Synonyms:11-deoxy-16,16-trimethyleneprostaglandin E1;11-deoxy-16,16-trimethyleneprostaglandin E1, (1alpha,2beta(1E,3R*))-(+-)-isomer

Suppliers and Price of 7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxyprop-1-enyl]-5-oxocyclopentyl]heptanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxyprop-1-enyl]-5-oxocyclopentyl]heptanoic acid

Chemical Property:

Vapor Pressure:4.25E-14mmHg at 25°C
Boiling Point:543.9°Cat760mmHg
Flash Point:296.8°C
Density:1.089g/cm³
XLogP3:4.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:13
Exact Mass:378.27700969
Heavy Atom Count:27
Complexity:507

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC1(CCC1)C(C=CC2CCC(=O)C2CCCCCCC(=O)O)O
Isomeric SMILES:CCCCC1(CCC1)[C@H](/C=C/[C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)O

Technology Process of 7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxyprop-1-enyl]-5-oxocyclopentyl]heptanoic acid

There total 10 articles about 7-[(1R,2R)-2-[(E,3S)-3-(1-butylcyclobutyl)-3-hydroxyprop-1-enyl]-5-oxocyclopentyl]heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 15-hydroxy-9-oxo-16,16-trimethylene-13-trans-prostenoate

: 62407-92-5
9-oxo-15-hydroxy-16,16-trimethylene-13-trans-prostenoic acid

Guidance literature:: With potassium hydroxide; In hydrogenchloride; methanol hydrate;

Reference yield:

: 62407-91-4,62446-40-6
dl-11-Deoxy-16,16-trimethylenprostaglandin E⁽¹⁾-ethylester

: 62407-92-5
dl-11-Deoxy-16,16-trimethylenprostaglandin E(1)

Guidance literature:: With potassium hydroxide; In methanol; Heating;
DOI:10.1021/jm00218a010

Reference yield:

: 14924-53-9
ethyl cyclobutylcarboxylate

: 62407-92-5
dl-11-Deoxy-16,16-trimethylenprostaglandin E(1)

Guidance literature:: Multi-step reaction with 8 steps

1: (i) cyclohexyl-isopropyl-amine
, THF, hexane, (ii) /BRN= 1420755/, DMSO

2: iBu₂AlH / toluene

3: CrO₃, Py / CH₂Cl₂

4: dimethylsulfoxide

5: imidazole / dimethylformamide

8: aq. KOH / methanol / Heating

With pyridine; 1H-imidazole; chromium(VI) oxide; potassium hydroxide; diisobutylaluminium hydride; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00218a010