[(1S,4R)-4-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopent-2-en-1-yl]methanol

Base Information

Chemical Name:[(1S,4R)-4-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopent-2-en-1-yl]methanol
CAS No.:122624-83-3
Molecular Formula:C₁₀H₁₃N₇O
Molecular Weight:247.26
Hs Code.:

Synonyms:2-Cyclopentene-1-methanol,4-(5,7-diamino-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-, cis- (9CI);2-Cyclopentene-1-methanol,4-(5,7-diamino-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-, cis-(?à)-;3H-1,2,3-Triazolo[4,5-d]pyrimidine, 2-cyclopentene-1-methanol dedriv. (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(1S,4R)-4-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopent-2-en-1-yl]methanol

Chemical Property:

Vapor Pressure:7.7E-18mmHg at 25°C
Boiling Point:651.1°Cat760mmHg
Flash Point:347.6°C
Density:1.92g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [(1S,4R)-4-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopent-2-en-1-yl]methanol

There total 6 articles about [(1S,4R)-4-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopent-2-en-1-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 122624-79-7
(+/-)-cis-<4-(5-amino-7-chloro-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-2-cyclopentenyl>carbinol

: 122624-83-3
(+/-)-cis-<4-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-2-cyclopentenyl>carbinol

Guidance literature:: With ammonia; In methanol; at 60 ℃; for 20h;
DOI:10.1021/jm00163a004

Reference yield:

: 229177-39-3
1-amino-4-(hydroxymethyl)-2-cyclopentene

: 122624-83-3
(+/-)-cis-<4-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-2-cyclopentenyl>carbinol

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / butan-1-ol / 48 h / Heating

2: 1.) 3 N HCl, sodium nitrite, 2.) sodium acetate trihydrate / 1.) water, 2.) acetic acid, water, RT, overnight

3: 66 percent / Zn, acetic acid / H₂O; ethanol / 3 h / Heating

4: 81 percent / sodium nitrite, acetic acid / H₂O / 1 h / 0 °C

5: 83 percent / liquid ammonia / methanol / 20 h / 60 °C

With hydrogenchloride; ammonia; sodium acetate; acetic acid; triethylamine; zinc; sodium nitrite; In methanol; ethanol; water; butan-1-ol;
DOI:10.1021/jm00163a004

Reference yield:

: 61865-50-7,86252-77-9
Acetic acid 4-acetylamino-cyclopent-2-enylmethyl ester

: 122624-83-3
(+/-)-cis-<4-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-2-cyclopentenyl>carbinol

Guidance literature:: Multi-step reaction with 6 steps

1: 0.5 N aq. barium hydroxide / Heating; overnight

2: Et₃N / butan-1-ol / 48 h / Heating

3: 1.) 3 N HCl, sodium nitrite, 2.) sodium acetate trihydrate / 1.) water, 2.) acetic acid, water, RT, overnight

4: 66 percent / Zn, acetic acid / H₂O; ethanol / 3 h / Heating

5: 81 percent / sodium nitrite, acetic acid / H₂O / 1 h / 0 °C

6: 83 percent / liquid ammonia / methanol / 20 h / 60 °C

With hydrogenchloride; barium dihydroxide; ammonia; sodium acetate; acetic acid; triethylamine; zinc; sodium nitrite; In methanol; ethanol; water; butan-1-ol;
DOI:10.1021/jm00163a004