2-Bromo-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

Base Information

• Chemical Name: 2-Bromo-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
• CAS No.: 40027-72-3
• Molecular Formula: C₁₁H₁₃BrN₂O₅
• Molecular Weight: 333.139
• Mol file: 40027-72-3.mol

Synonyms:(1RS,2RS)-2-[2-Brom-acetylamino]-1-[4-nitro-phenyl]-propan]-1,3-diol;2-Bromo-N-[(1S,2S)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethyl]-acetamide;Bromessigsaeure-[(1RS,2RS)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-aethylamid];

Chemical Property of 2-Bromo-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

Chemical Property:

• Vapor Pressure: 4.62E-17mmHg at 25°C
• Boiling Point: 636.3°C at 760 mmHg
• Flash Point: 338.6°C
• PSA: 115.38000
• Density: 1.675g/cm³
• LogP: 1.41430
• Solubility.: Dichloromethane; Ethyl Acetate

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Bromamphenicol is a semi-synthetic chloramphenicol analogue.

Technology Process of 2-Bromo-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

There total 2 articles about 2-Bromo-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol (119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0) + 2-Bromoacetyl bromide (598-21-0) → bromoacetic acid-[(1RS,2RS)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylamide] (40027-72-3)

Guidance literature:

With sodium hydrogencarbonate; ethyl acetate;

DOI:10.1021/ja01166a129

Reference yield:

2-bromoacetyl chloride (22118-09-8) + (+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol (119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0) → bromoacetic acid-[(1RS,2RS)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylamide] (40027-72-3)

Guidance literature:

With sodium hydrogencarbonate; acetone;

upstream raw materials:

2-bromoacetyl chloride

(+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol

2-Bromoacetyl bromide

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