6-Chloro-3-fluoro-2-hydroxy-7-methoxy-3-phenylquinolin-4(3H)-one

Base Information

Chemical Name:6-Chloro-3-fluoro-2-hydroxy-7-methoxy-3-phenylquinolin-4(3H)-one
CAS No.:144603-88-3
Molecular Formula:C16H11 Cl F N O3
Molecular Weight:319.7148
Hs Code.:
DSSTox Substance ID:DTXSID10932363
Wikidata:Q82908060
Mol file:144603-88-3.mol

Synonyms:DTXSID10932363;6-Chloro-3-fluoro-2-hydroxy-7-methoxy-3-phenylquinolin-4(3H)-one;144603-88-3

Suppliers and Price of 6-Chloro-3-fluoro-2-hydroxy-7-methoxy-3-phenylquinolin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-Chloro-3-fluoro-2-hydroxy-7-methoxy-3-phenylquinolin-4(3H)-one

Chemical Property:

Vapor Pressure:9.81E-11mmHg at 25°C
Boiling Point:515.5°Cat760mmHg
Flash Point:265.6°C
Density:1.44g/cm³
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:319.0411491
Heavy Atom Count:22
Complexity:468

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)NC(=O)C(C2=O)(C3=CC=CC=C3)F)Cl
Isomeric SMILES:COC1=C(C=C2C(=C1)NC(=O)[C@@](C2=O)(C3=CC=CC=C3)F)Cl

Technology Process of 6-Chloro-3-fluoro-2-hydroxy-7-methoxy-3-phenylquinolin-4(3H)-one

There total 2 articles about 6-Chloro-3-fluoro-2-hydroxy-7-methoxy-3-phenylquinolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 144603-49-6
3,6-dichloro-7-methoxy-3-phenylquinoline-2,4(1H,3H)-dione

: 144603-88-3
6-Chloro-3-fluoro-7-methoxy-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: With potassium fluoride; 18-crown-6 ether; In acetonitrile; for 6h; Heating;
DOI:10.1007/BF00816857

Reference yield:

: 28563-22-6
4-hydroxy-7-methoxy-3-phenyl-2(1H)-quinolinone

: 144603-88-3
6-Chloro-3-fluoro-7-methoxy-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / SO₂Cl₂ / dioxane / 0.17 h / 40 - 60 °C

2: 78 percent / KF, 18-crown-6 / acetonitrile / 6 h / Heating

With potassium fluoride; sulfuryl dichloride; 18-crown-6 ether; In 1,4-dioxane; acetonitrile;
DOI:10.1007/BF00816857