7-Chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-3-cinnolinecarboxylic acid

Base Information

Chemical Name:7-Chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-3-cinnolinecarboxylic acid
CAS No.:159831-79-5
Molecular Formula:C₁₆H₉ClFN₃O₃
Molecular Weight:345.717
Hs Code.:
DSSTox Substance ID:DTXSID70936180
Mol file:159831-79-5.mol

Synonyms:159831-79-5;7-Chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-3-cinnolinecarboxylic acid;3-Cinnolinecarboxylic acid, 7-chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-;7-Chloro-6-fluoro-4-((4-hydroxybenzylidene)amino)cinnoline-3-carboxylic acid;C16H9ClFN3O3;DTXSID70936180;C16-H9-Cl-F-N3-O3;LS-54281;7-CHLORO-6-FLUORO-4-{[(4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)METHYL]AMINO}CINNOLINE-3-CARBOXYLIC ACID

Suppliers and Price of 7-Chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-3-cinnolinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-3-cinnolinecarboxylic acid

Chemical Property:

Vapor Pressure:4.88E-14mmHg at 25°C
Boiling Point:574.5°Cat760mmHg
Flash Point:301.2°C
Density:1.7g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:345.0316470
Heavy Atom Count:24
Complexity:487

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C=NC2=C(N=NC3=CC(=C(C=C32)F)Cl)C(=O)O)O

Technology Process of 7-Chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-3-cinnolinecarboxylic acid

There total 4 articles about 7-Chloro-6-fluoro-4-(((4-hydroxyphenyl)methylene)amino)-3-cinnolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 159831-73-9
4-amino-7-chloro-6-fluorocinnoline-3-carboxylic acid

: 159831-79-5
7-Chloro-6-fluoro-4-{[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cinnoline-3-carboxylic acid

Guidance literature:: In ethanol; for 3h; Heating;

Reference yield:

: C₆H₃Cl₂FN₂

: 159831-79-5
7-Chloro-6-fluoro-4-{[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cinnoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / sodium acetate / H₂O; ethanol / 3 h / 0 °C

2: 45 percent / AlCl₃ / chlorobenzene / 1 h / Heating

3: 60 percent / KOH / ethanol / 3 h / Heating

4: 30 percent / ethanol / 3 h / Heating

With potassium hydroxide; aluminium trichloride; sodium acetate; In ethanol; water; chlorobenzene;

Reference yield:

: 159831-72-8
4-amino-7-chloro-6-fluorocinnoline-3-carboxamide

: 159831-79-5
7-Chloro-6-fluoro-4-{[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cinnoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / KOH / ethanol / 3 h / Heating

2: 30 percent / ethanol / 3 h / Heating

With potassium hydroxide; In ethanol;