4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydro-1H-quinazoline-2-thione

Base Information

Chemical Name:4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydro-1H-quinazoline-2-thione
CAS No.:65331-18-2
Molecular Formula:C14H15ClN2S
Molecular Weight:278.805
Hs Code.:
DSSTox Substance ID:DTXSID80407412

Synonyms:65331-18-2;ST50996064;DTXSID80407412;AKOS024364125

Suppliers and Price of 4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydro-1H-quinazoline-2-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydro-1H-quinazoline-2-thione

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:278.0644474
Heavy Atom Count:18
Complexity:372

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=C(C1)C(NC(=S)N2)C3=CC=C(C=C3)Cl

Technology Process of 4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydro-1H-quinazoline-2-thione

There total 5 articles about 4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydro-1H-quinazoline-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 104-88-1
4-chlorobenzaldehyde

: 17356-08-0
thiourea

: 65331-18-2
4-(4-chlorophenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione

Guidance literature:: With chloro-trimethyl-silane; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃;
DOI:10.1002/ejoc.200400845

Reference yield: 62.0%

: 31021-05-3
(E)-2-(4-chlorobenzylidene)cyclohexanone

: 17356-08-0
thiourea

: 65331-18-2
4-(4-chlorophenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione

Guidance literature:: With potassium hydroxide; In ethanol; for 3h; Heating;
DOI:10.1515/HC.2006.12.5.389

Reference yield: 61.15%

: 31020-78-7,31021-05-3,24765-16-0
2-(4-chlorobenzylidene)cyclohexan-1-one

: 17356-08-0
thiourea

: 65331-18-2
4-(4-chlorophenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione

Guidance literature:: 2-(4-chlorobenzylidene)cyclohexan-1-one; thiourea; With potassium hydroxide; In ethanol; for 4h; Reflux;

With acetic acid; In ethanol; water;
DOI:10.1002/ardp.200700153