2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE

Base Information

• Chemical Name: 2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE
• CAS No.: 5805-30-1
• Molecular Formula: C15H14N2
• Molecular Weight: 222.29
• Hs Code.: 2933990090
• Mol file: 5805-30-1.mol

Synonyms:2-phenethyl-1H-benzimidazole;2-Phenethyl-1H-benzoimidazole;

Chemical Property of 2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE

Chemical Property:

• Vapor Pressure: 5E-08mmHg at 25°C
• Boiling Point: 454.8°Cat760mmHg
• Flash Point: 247.8°C
• PSA: 28.68000
• Density: 1.178g/cm³
• LogP: 3.34810

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-phenylethyl)-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE

There total 21 articles about 2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(2-aminophenyl)-3-phenylpropanamide (954567-41-0) → 2-phenethyl-1H-benzo[d]imidazole (5805-30-1)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In toluene; for 3h; Reflux;

DOI:10.1039/C8RA07773H

Reference yield: 92.0%

3-phenyl-propionaldehyde (104-53-0) + 1,2-diamino-benzene (95-54-5) → 2-phenethyl-1H-benzo[d]imidazole (5805-30-1)

Guidance literature:

With silica-bound phosphoric acid; In water; at 70 ℃; for 0.0833333h;

DOI:10.1007/s10593-014-1445-z

Reference yield: 91.0%

1,2-diamino-benzene (95-54-5) + 3-Phenylpropionic acid (501-52-0) → 2-phenethyl-1H-benzo[d]imidazole (5805-30-1)

Guidance literature:

In ethylene glycol; at 135 - 140 ℃; for 4h;

DOI:10.1007/s00044-005-0125-z

upstream raw materials:

1,2-diamino-benzene

3-Phenylpropionic acid

3-Phenyl-1-propanol

(2E)-3-phenyl-2-propen-1-ol

Downstream raw materials:

1-isobutyl-2-(2-phenylethyl)-1H-benzimidazole

Refernces

• 1、 Skolia, Elpida,Apostolopoulou, Mary K.,Nikitas, Nikolaos F.,Kokotos, Christoforos G.. "Photochemical Synthesis of Benzimidazoles from Diamines and Aldehydes". supporting information. p. 422 - 428. Retrieved 2020/12/13.
• 2、 Barasa, Leonard,Yoganathan, Sabesan. "An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology". . p. 35824 - 35830. Retrieved 2018/10/31.