2-[2-(1H-Indol-2-yl)-2-(1H-indol-3-yl)ethyl]aniline

Base Information

• Chemical Name: 2-[2-(1H-Indol-2-yl)-2-(1H-indol-3-yl)ethyl]aniline
• CAS No.: 65439-77-2
• Molecular Formula: C24H21N3
• Molecular Weight: 351.451
• DSSTox Substance ID: DTXSID60495211
• Mol file: 65439-77-2.mol

Synonyms:65439-77-2;2-[2-(1H-Indol-2-yl)-2-(1H-indol-3-yl)ethyl]aniline;DTXSID60495211

Chemical Property of 2-[2-(1H-Indol-2-yl)-2-(1H-indol-3-yl)ethyl]aniline

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 351.173547683
• Heavy Atom Count: 27
• Complexity: 494

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(N2)C(CC3=CC=CC=C3N)C4=CNC5=CC=CC=C54

Technology Process of 2-[2-(1H-Indol-2-yl)-2-(1H-indol-3-yl)ethyl]aniline

There total 8 articles about 2-[2-(1H-Indol-2-yl)-2-(1H-indol-3-yl)ethyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.7%

indole (120-72-9) → 2,3'-(o-aminophenethylidene)di-indole (65439-77-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 3h; Heating;

Reference yield: 6.7%

indole (120-72-9) → 2-(2,2-di(1H-indol-3-yl)ethyl)aniline (6941-73-7) + 3-(indolin-2-yl)indole + 2,3'-(o-aminophenethylidene)di-indole (65439-77-2)

Guidance literature:

With zinc(II) chloride; In acetic acid; at 100 - 105 ℃; for 4h; Product distribution; Mechanism; reactions under var. acid conditions;

Reference yield: 5.0%

2-(2,2-di(1H-indol-3-yl)ethyl)aniline (6941-73-7) → indole (120-72-9) + 3-(indolin-2-yl)indole + 2,3'-(o-aminophenethylidene)di-indole (65439-77-2)

Guidance literature:

With boron trifluoride diethyl etherate; for 120h; Product distribution; Ambient temperature; reactions under various acid conditions;

upstream raw materials:

indole

3-bromoindole

2-(2,2-di(1H-indol-3-yl)ethyl)aniline

2,3'-(o-nitrophenethylidene)di-indole

Downstream raw materials:

indole

2-(2-acetamidobenzyl)-3-(3'-indolyl)-quinoline

2,3'-(o-acetamidophenethylidene)di-indole

3-formyl-2,3'-(o-acetamidophenethylidene)di-indole