3-CHLORO-N-PYRIDIN-2-YL-1-BENZOTHIOPHENE-2-CARBOXAMIDE

Base Information

• Chemical Name: 3-CHLORO-N-PYRIDIN-2-YL-1-BENZOTHIOPHENE-2-CARBOXAMIDE
• CAS No.: 65469-38-7
• Molecular Formula: C14H9ClN2OS
• Molecular Weight: 288.75200
• Mol file: 65469-38-7.mol

Synonyms:3-chloro-N-(pyridin-2-yl)benzo[b]thiophene-2-carboxamide;3-Chloro-benzo[b]thiophene-2-carboxylic acid pyridin-2-ylamide;3-chloro-N-(2-pyridyl)benzo[b]thiophene-2-carboxamide;

Chemical Property of 3-CHLORO-N-PYRIDIN-2-YL-1-BENZOTHIOPHENE-2-CARBOXAMIDE

Chemical Property:

• Melting Point: 167 - 168 °C (ethanol)
• PSA: 70.23000
• LogP: 4.27500

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-CHLORO-N-PYRIDIN-2-YL-1-BENZOTHIOPHENE-2-CARBOXAMIDE

There total 2 articles about 3-CHLORO-N-PYRIDIN-2-YL-1-BENZOTHIOPHENE-2-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-aminopyridine (504-29-0) + 3-chlorobenzo[b]thiophen-2-carbonyl chloride (21815-91-8) → 3-chloro-N-(2-pyridyl)benzothiophene-2-carboxamide (65469-38-7)

Guidance literature:

With pyridine; In benzene; for 1h; Heating;

Reference yield:

Cinnamic acid (621-82-9) → 3-chloro-N-(2-pyridyl)benzothiophene-2-carboxamide (65469-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; pyridine / chlorobenzene / 2 h / 130 °C

2: 1,4-dioxane / Reflux

With pyridine; thionyl chloride; In 1,4-dioxane; chlorobenzene;

DOI:10.1021/acs.jmedchem.6b01685

upstream raw materials:

2-aminopyridine

3-chlorobenzo[b]thiophen-2-carbonyl chloride

Cinnamic acid

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