Pyrrolidine, 1-(2-(4-(2,3-dihydro-5-methoxy-2-phenyl-1H-inden-1-yl)phenoxy)ethyl)-, trans-

Base Information

Chemical Name:Pyrrolidine, 1-(2-(4-(2,3-dihydro-5-methoxy-2-phenyl-1H-inden-1-yl)phenoxy)ethyl)-, trans-
CAS No.:78014-14-9
Molecular Formula:C₂₈H₃₁NO₂
Molecular Weight:413.56
Hs Code.:

Synonyms:1-(2-(4-(2,3-dihydro-5-methoxy-2-phenyl-1H-inden-1-yl)phenoxy)ethyl)pyrrolidine;1-(4-(pyrrolidinoethoxy)phenyl)-2-phenyl-5-methoxyindan;E 1487;E-1487

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolidine, 1-(2-(4-(2,3-dihydro-5-methoxy-2-phenyl-1H-inden-1-yl)phenoxy)ethyl)-, trans-

Chemical Property:

Vapor Pressure:2.71E-11mmHg at 25°C
Boiling Point:529.4°Cat760mmHg
Flash Point:156.3°C
Density:1.126g/cm³
XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:413.235479232
Heavy Atom Count:31
Complexity:533

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(C(C2)C3=CC=CC=C3)C4=CC=C(C=C4)OCCN5CCCC5

Technology Process of Pyrrolidine, 1-(2-(4-(2,3-dihydro-5-methoxy-2-phenyl-1H-inden-1-yl)phenoxy)ethyl)-, trans-

There total 16 articles about Pyrrolidine, 1-(2-(4-(2,3-dihydro-5-methoxy-2-phenyl-1H-inden-1-yl)phenoxy)ethyl)-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 78014-08-1,118848-49-0
1,2-cis-1-(p-hydroxyphenyl)-5-methoxy-2-phenylindane

: 78014-14-9,118848-44-5
1,2-cis-1-(p-(β-pyrrolidinoethoxy)phenyl)-5-methoxy-2-phenyl-indane

Guidance literature:: With potassium carbonate; In acetone; for 12h; Heating;
DOI:10.1016/0223-5234(89)90115-3

Reference yield: 77.0%

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 78014-08-1,118848-49-0
1,2-trans-1-(p-hydroxyphenyl)-5-methoxy-2-phenylindane

: 78014-14-9,118848-44-5
1,2-trans-1--2-phenyl-5-methoxyindane

Guidance literature:: With potassium carbonate; In acetone; Heating;

Reference yield:

: 103-82-2
phenylacetic acid

: 78014-14-9,118848-44-5
1,2-trans-1--2-phenyl-5-methoxyindane

Guidance literature:: Multi-step reaction with 7 steps

1: polyphosphoric acid / 0.5 h / Heating

2: 35 percent / NaOMe / 4 h / Heating

3: 95 percent / hydrogen / 10 percent Pd-C / ethyl acetate

4: 45 percent / anhydrous AlCl₃ / benzene / 3.5 h / Heating

5: 90 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

6: 58 percent / p-TsOH / benzene / 2 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; PPA; hydrogen; sodium methylate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1016/0223-5234(89)90115-3