3,4-Dihydro-2-methyl-1(2H)-isoquinolinethione

Base Information

• Chemical Name: 3,4-Dihydro-2-methyl-1(2H)-isoquinolinethione
• CAS No.: 6552-61-0
• Molecular Formula: C₁₀H₁₁NS
• Molecular Weight: 177.27
• Mol file: 6552-61-0.mol

Synonyms:2-Methyl-3,4-dihydro-2H-isoquinoline-1-thione;N-Methyl-1,2,3,4-tetrahydroisochinolin-1-thion;

Chemical Property of 3,4-Dihydro-2-methyl-1(2H)-isoquinolinethione

Chemical Property:

• PSA: 35.33000
• LogP: 1.78790

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydro-2-methyl-1(2H)-isoquinolinethione

There total 2 articles about 3,4-Dihydro-2-methyl-1(2H)-isoquinolinethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-methyl-1,2,3,4-tetrahydroisoquinoline (1612-65-3) → 2-methyl-3,4-dihydro-1(2H)-isoquinolinethione (6552-61-0)

Guidance literature:

With sulfur; In pyridine; 1.) 5 h, 100 deg C, 2.) 12 h, r.t.;

Reference yield:

2-methyl-3,4-dihydro-2H-isoquinolin-1-one (6772-65-2) → 2-methyl-3,4-dihydro-1(2H)-isoquinolinethione (6552-61-0)

Guidance literature:

With Lawessons reagent; In toluene;

DOI:10.1016/j.bmc.2005.10.044

Reference yield:

2-methyl-3,4-dihydro-1(2H)-isoquinolinethione (6552-61-0) + aniline (62-53-3) → N-(2-methyl-3,4-dihydroisoquinolin-1(2H)-ylidene)aniline

Guidance literature:

With mercury(II) diacetate; In toluene; Heating;

DOI:10.1016/j.bmc.2005.10.044

upstream raw materials:

2-methyl-1,2,3,4-tetrahydroisoquinoline

2-methyl-3,4-dihydro-2H-isoquinolin-1-one