1-Methoxy-4-phenylbicyclo[2.2.2]octane

Base Information

• Chemical Name: 1-Methoxy-4-phenylbicyclo[2.2.2]octane
• CAS No.: 6555-88-0
• Molecular Formula: C15H20O
• Molecular Weight: 216.31900
• Hs Code.: 2909309090
• Mol file: 6555-88-0.mol

Synonyms:4-Phenyl-1-methoxy-bicyclo[2.2.2]octan;1-Methoxy-4-phenylbicyclo[2.2.2]octan;1-Methoxy-4-phenyl-bicyclo[2.2.2]octan;

Chemical Property of 1-Methoxy-4-phenylbicyclo[2.2.2]octane

Chemical Property:

• PSA: 9.23000
• LogP: 3.67740

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methoxy-4-phenylbicyclo[2.2.2]octane

There total 2 articles about 1-Methoxy-4-phenylbicyclo[2.2.2]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Methoxy-1-phenyl-bicyclo<2.2.2>-octan-2-on (3850-62-2) → 1-methoxy-4-phenylbicyclo[2.2.2]octane (6555-88-0)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol; Heating;

DOI:10.1021/ja00744a016

Reference yield:

4-acetyl-4-methyl cyclohexanone (6848-93-7) → 1-methoxy-4-phenylbicyclo[2.2.2]octane (6555-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl

2: N₂H₄*H₂O, KOH / bis-(2-hydroxy-ethyl) ether / Heating

With hydrogenchloride; potassium hydroxide; hydrazine hydrate; In diethylene glycol;

Reference yield:

1-methoxy-4-phenylbicyclo[2.2.2]octane (6555-88-0) → 1,4-bis-(4-cyanophenyl)bicyclo[2.2.2]octane (33732-72-8)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂, SnCl₄

2: FeCl₃ / Heating

3: Br₂, Fe

4: N-methylpyrrolidone / 195 - 200 °C

With 1-methyl-pyrrolidin-2-one; thionyl chloride; bromine; iron(III) chloride; tin(IV) chloride; iron;

DOI:10.1021/ja00744a016

upstream raw materials:

4-Methoxy-1-phenyl-bicyclo<2.2.2>-octan-2-on

4-acetyl-4-methyl cyclohexanone

Downstream raw materials:

4-Methoxy-1-(p-Nitrophenyl)-bicyclo<2.2.2>-octan

1-chloro-4-phenylbicyclo<2.2.2>octane

1,4-bis-(4-cyanophenyl)bicyclo[2.2.2]octane

1,4-Diphenyl-bicyclo<2.2.2>octane