[4-(Benzyloxy)-3-hydroxyphenyl]acetonitrile p-Toluenesulfonate

Base Information

• Chemical Name: [4-(Benzyloxy)-3-hydroxyphenyl]acetonitrile p-Toluenesulfonate
• CAS No.: 65615-26-1
• Molecular Formula: C22H19NO4S
• Molecular Weight: 411.47100
• Hs Code.: 2926909090
• Mol file: 65615-26-1.mol

Synonyms:3-[[(4-methylphenyl)sulfonyl]oxy]-4-(phenylmethoxy)benzeneacetonitrile;3-TOSYLOXY-4-BENZYLOXYBENZYL CYANIDE;4-benzyloxy-3-tosyloxybenzylcyanide;4-Benzyloxy-3-tosyloxy-benzylcyanid;[4-(Benzyloxy)-3-hydroxyphenyl]acetonitrile p-Toluenesulfonate;

Chemical Property of [4-(Benzyloxy)-3-hydroxyphenyl]acetonitrile p-Toluenesulfonate

Chemical Property:

• PSA: 116.00000
• LogP: 5.35978
• Solubility.: Chloroform

Purity/Quality:

97% ^*data from raw suppliers

3-Tosyloxy-4-benzyloxybenzylCyanide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Tosyloxy-4-benzyloxybenzyl Cyanide (cas# 65615-26-1) is a compound useful in organic synthesis.

Technology Process of [4-(Benzyloxy)-3-hydroxyphenyl]acetonitrile p-Toluenesulfonate

There total 3 articles about [4-(Benzyloxy)-3-hydroxyphenyl]acetonitrile p-Toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Benzyloxy-3-tosyloxy-benzaldehyd (65615-20-5) → 4-benzyloxy-3-tosyloxybenzylcyanide (65615-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / methanol

2: SOCl₂

3: dimethylformamide

With sodium tetrahydroborate; thionyl chloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19630460718

Reference yield:

4-Benzyloxy-3-tosyloxy-benzylalkohol (65615-21-6) → 4-benzyloxy-3-tosyloxybenzylcyanide (65615-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: dimethylformamide

With thionyl chloride; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19630460718

Reference yield:

4-Benzyloxy-3-tosyloxy-benzylchlorid (65615-25-0) + sodium cyanide (143-33-9,25596-52-5) → 4-benzyloxy-3-tosyloxybenzylcyanide (65615-26-1)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19630460718

upstream raw materials:

4-Benzyloxy-3-tosyloxy-benzylchlorid

sodium cyanide

4-Benzyloxy-3-tosyloxy-benzaldehyd

4-Benzyloxy-3-tosyloxy-benzylalkohol

Downstream raw materials:

4-benzyloxy-3-tosyloxyphenethylamine

4-Benzyloxy-3-hydroxy-benzylcyanid

Dopamine 3-O-sulfate

3-Sulfoxy-4-benzyloxy-phenethylamin