Sec-butylamine

Base Information

• Chemical Name: Sec-butylamine
• CAS No.: 13952-84-6
• Deprecated CAS: 33966-50-6
• Molecular Formula: C4H11N
• Molecular Weight: 73.14
• Hs Code.: 2921.19
• European Community (EC) Number: 237-732-7,684-161-8
• ICSC Number: 0401
• NSC Number: 8030
• UN Number: 2735,1992,2924
• UNII: QAZ452YGSG
• DSSTox Substance ID: DTXSID4022284
• Nikkaji Number: J8.464F
• Wikipedia: Sec-Butylamine
• Wikidata: Q288208
• Metabolomics Workbench ID: 45314
• ChEMBL ID: CHEMBL3186956
• Mol file: 13952-84-6.mol

Synonyms:SEC-BUTYLAMINE;butan-2-amine;2-Butanamine;13952-84-6;2-Aminobutane;2-Butylamine;1-Methylpropylamine;Tutane;Butafume;1-Methylpropanamine;Deccotane;Frucote;(RS)-sec-Butylamine;2-Aminobutane base;s-butylamine;(+/-)-2-Aminobutane;Butylamine [ISO];Secondary butylamine;2-AB;sec-butyl amine;(+-)-sec-butylamine;Caswell No. 125;Propylamine, 1-methyl;sec-Butanamine;sec.-butylamine;(+/-)-sec-Butylamine;NSC 8030;DL-2-Butylamine;2-AB (VAN);CCRIS 4757;(Rs)-2-aminobutane;33966-50-6;HSDB 6312;Propylamine, 1-methyl-;EINECS 237-732-7;UNII-QAZ452YGSG;MFCD00008094;QAZ452YGSG;EPA Pesticide Chemical Code 004214;AI3-35093;DTXSID4022284;CHEBI:74526;2-Butanamine, hydrochloride;NSC-8030;sec-Butylamine, (S)-;DL-sec-Butylamine;Mono-sec-butylamine;sec butylamine;sec-butylamin;sec.butylamine;sec- butylamine;s-butyl amine;Sec. Butylamine;2-amino-butane;monosec.butylamine;secondarybutylamine;Butylamine, sec-;methyl-1-propanamine;racemic 2-butylamine;1-Methyl-Propylamine;sec-Butylamine (ACN;(-)-sec-Butylamine;(+/-)-secbutylamine;sec-Butylamine, 99%;sec-C4H9NH2;.+/-.-sec-Butylamine;(+/-)-2-Butylamine;(rs)-1-methylpropylamine;(+/-)-sec-butyl amine;(.+/-.)-sec-Butylamine;NCIOpen2_009269;SEC-BUTYLAMINE [MI];SEC-BUTYLAMINE [FHFI];SEC-BUTYLAMINE [HSDB];Butylamine (sec) Reagent Grade;DTXCID602284;WLN: ZY2&1;2-Butanamine, (.+/-.)-;CHEMBL3186956;FEMA NO. 4240;(+/-)-sec-Butylamine, 99%;NSC8030;sec-Butylamine, analytical standard;STR00953;SEC-BUTYLAMINE DL-FORM [MI];Tox21_301321;LS-815;STL194265;AKOS000119064;AKOS016352717;NCGC00255387-01;LS-47360;CAS-13952-84-6;B0708;FT-0604436;FT-0605042;FT-0656930;FT-0691583;EN300-19017;C18706;A806444;A828547;Q288208;J-007288;F2190-0361;Z104472234;1-sec-Butylamine, salt with d-3-bromo-x-camphorsulfonic acid;SEC-BUTYLAMINE (SEE ALSO: N-BUTYLAMINE (CAS 109-73-9) & TERT-BUTYLAMINE (CAS 75-64-9))

Chemical Property of Sec-butylamine

Chemical Property:

• Appearance/Colour: colourless liquid with an amine odour
• Vapor Pressure: 175mmHg at 25°C
• Melting Point: -104 °C
• Refractive Index: 1.3934
• Boiling Point: 62.9 °C at 760 mmHg
• Flash Point: -19 °C
• PSA: 26.02000
• Density: 0.741 g/cm³
• LogP: 1.44390
• Water Solubility.: MISCIBLE
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 73.089149355
• Heavy Atom Count: 5
• Complexity: 19.6
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): F, C, N
• Hazard Codes: F:Flammable;;
• Statements: R11:; R20/22:; R35:; R50:
• Safety Statements: S16:; S26:; S28A:; S36/37/39:; S45:; S61:; S9:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CCC(C)N
• Inhalation Risk: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis.

Refernces

A comparative reactivity survey of some prominent bisphosphine nickel(II) precatalysts in C-N cross-coupling

10.1021/acs.organomet.6b00650

The research investigates the comparative reactivity of three bisphosphine nickel(II) precatalysts—namely (L1)Ni(o-tol)Cl (C1), (L2)Ni(o-tol)Cl (C2), and (L3)Ni(o-tol)Cl (C3)—in nickel-catalyzed C(sp2)?N cross-coupling reactions. The study aims to evaluate how ancillary ligands influence catalytic performance in these transformations, which are essential for synthesizing biologically active molecules and functional materials. The chemicals used include ammonia, primary alkylamines such as furfurylamine and sec-butylamine, secondary dialkylamines like morpholine, and a range of aryl electrophiles including chlorides, bromides, and tosylates. The newly synthesized air-stable precatalyst C1, featuring an electron-rich JosiPhos CyPF-Cy ligand, was found to be competitive with and sometimes complementary to C2, especially in challenging room-temperature monoarylations of ammonia and primary alkylamines with (hetero)aryl chlorides.