10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol

Base Information

Chemical Name:10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol
CAS No.:17895-95-3
Molecular Formula:C14H13NO
Molecular Weight:211.2591
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90939133
Nikkaji Number:J41.275I
Mol file:17895-95-3.mol

Synonyms:17895-95-3;BRN 1533336;10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol;10,11-Dihydro-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-ol;5H-BENZO(4,5)CYCLOHEPTA(1,2-b)PYRIDIN-5-OL, 10,11-DIHYDRO-;7-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-ol;5H-Benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol, 10,11-dihydro-;SCHEMBL10415991;DTXSID90939133;LS-33782;5-hydroxy-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine

Suppliers and Price of 10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol

Chemical Property:

Vapor Pressure:5.5E-06mmHg at 25°C
Boiling Point:365.5°Cat760mmHg
Flash Point:174.9°C
PSA：33.12000
Density:1.214g/cm³
LogP:2.26190
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:211.099714038
Heavy Atom Count:16
Complexity:243

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C=CC=N2)C(C3=CC=CC=C31)O

Technology Process of 10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol

There total 6 articles about 10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422960-66-4
2-phenethyl-3-pyridinecarboxaldehyde

: 17895-95-3
10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol

Guidance literature:: 2-phenethyl-3-pyridinecarboxaldehyde; With trifluorormethanesulfonic acid; trifluoroacetic acid; at 25 ℃; for 2h; Inert atmosphere;

With sodium hydroxide; In water; Inert atmosphere;
DOI:10.1016/j.tet.2013.01.004

Reference yield:

: 128071-75-0
2-bromopyridine-3-carboxaldehyde

: 17895-95-3
10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / Inert atmosphere; Reflux

2.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 2 h / 10343.2 Torr / Autoclave

3.1: manganese(IV) oxide / benzene / 12 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 2 h / 25 °C / Inert atmosphere

4.2: Inert atmosphere

With manganese(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluorormethanesulfonic acid; 5%-palladium/activated carbon; hydrogen; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethyl acetate; benzene; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.01.004

Reference yield:

: 536-74-3
phenylacetylene

: 17895-95-3
10,11-Dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / Inert atmosphere; Reflux

2.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 2 h / 10343.2 Torr / Autoclave

3.1: manganese(IV) oxide / benzene / 12 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 2 h / 25 °C / Inert atmosphere

4.2: Inert atmosphere

With manganese(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluorormethanesulfonic acid; 5%-palladium/activated carbon; hydrogen; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethyl acetate; benzene; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.01.004