2H-Isoindole-2-acetamide, N-[[1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1 H-1,2,4-triazol-5-yl]methyl]-1,3-dihydro-1,3-dioxo-

Base Information

• Chemical Name: 2H-Isoindole-2-acetamide, N-[[1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1 H-1,2,4-triazol-5-yl]methyl]-1,3-dihydro-1,3-dioxo-
• CAS No.: 65699-07-2
• Molecular Formula: C₂₉H₂₂ClFN₆O₅
• Molecular Weight: 588.982

Synonyms:

Chemical Property of 2H-Isoindole-2-acetamide, N-[[1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1 H-1,2,4-triazol-5-yl]methyl]-1,3-dihydro-1,3-dioxo-

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2H-Isoindole-2-acetamide, N-[[1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1 H-1,2,4-triazol-5-yl]methyl]-1,3-dihydro-1,3-dioxo-

There total 2 articles about 2H-Isoindole-2-acetamide, N-[[1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1 H-1,2,4-triazol-5-yl]methyl]-1,3-dihydro-1,3-dioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H16ClFN4O2 (65699-02-7) + phthalylglycylglycyl chloride (59180-28-8) → 1-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-5-{[(N,N-phthaloyl-glycyl)-amino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide (65699-07-2)

Guidance literature:

Yield given. Multistep reaction; 1) THF, hexamethylphosphoramide, r.t., 4 h, 2) acetic acid, reflux, 1.5 h;

DOI:10.1002/jhet.5570190621

Reference yield:

→ 1-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-5-{[(N,N-phthaloyl-glycyl)-amino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide (65699-07-2)

Guidance literature:

entspr.Phthalylglycylglycylchlorid,HOAc/entspr.Carbamoylhydrazin;

Reference yield:

1-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-5-{[(N,N-phthaloyl-glycyl)-amino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide (65699-07-2) → 1-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-5-(glycylamino-methyl)-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Heating;

DOI:10.1002/jhet.5570190621

upstream raw materials:

C₁₇H₁₆ClFN₄O₂

phthalylglycylglycyl chloride

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