Acetamide, 2-amino-N-[[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-(1-pyrrolidinylcarb onyl)-1H-1,2,4-triazol-5-yl]methyl]-

Base Information

• Chemical Name: Acetamide, 2-amino-N-[[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-(1-pyrrolidinylcarb onyl)-1H-1,2,4-triazol-5-yl]methyl]-
• CAS No.: 65699-13-0
• Molecular Formula: C23H22Cl2N6O3
• Molecular Weight: 501.372
• Mol file: 65699-13-0.mol

Synonyms:

Chemical Property of Acetamide, 2-amino-N-[[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-(1-pyrrolidinylcarb onyl)-1H-1,2,4-triazol-5-yl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, 2-amino-N-[[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-(1-pyrrolidinylcarb onyl)-1H-1,2,4-triazol-5-yl]methyl]-

There total 4 articles about Acetamide, 2-amino-N-[[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-(1-pyrrolidinylcarb onyl)-1H-1,2,4-triazol-5-yl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-{1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(N,N-phthaloyl-glycylamino)-methyl]-1H-[1,2,4]triazole-3-carbonyl}-pyrrolidine (65699-08-3) → 1-{1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-(glycylamino-methyl)-1H-[1,2,4]triazole-3-carbonyl}-pyrrolidine (65699-13-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Heating;

DOI:10.1002/jhet.5570190621

Reference yield:

C17H15Cl2N3O3 (65698-98-8) → 1-{1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-(glycylamino-methyl)-1H-[1,2,4]triazole-3-carbonyl}-pyrrolidine (65699-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / methanol / 96 h / Ambient temperature

2: 1) THF, hexamethylphosphoramide, r.t., 4 h, 2) acetic acid, reflux, 1.5 h

3: 90 percent / hydrazine hydrate / ethanol / 1 h / Heating

With hydrazine hydrate; In methanol; ethanol;

DOI:10.1002/jhet.5570190621

Reference yield:

C19H18Cl2N4O2 (65699-03-8) → 1-{1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-(glycylamino-methyl)-1H-[1,2,4]triazole-3-carbonyl}-pyrrolidine (65699-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) THF, hexamethylphosphoramide, r.t., 4 h, 2) acetic acid, reflux, 1.5 h

2: 90 percent / hydrazine hydrate / ethanol / 1 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.5570190621

upstream raw materials:

1-{1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(N,N-phthaloyl-glycylamino)-methyl]-1H-[1,2,4]triazole-3-carbonyl}-pyrrolidine

C₁₇H₁₅Cl₂N₃O₃

C₁₉H₁₈Cl₂N₄O₂