(R)-5-HYDROXY-2-HEXANONE

Base Information

• Chemical Name: (R)-5-HYDROXY-2-HEXANONE
• CAS No.: 65709-73-1
• Molecular Formula: C6H12O2
• Molecular Weight: 116.15800
• Hs Code.: 2914400090
• Mol file: 65709-73-1.mol

Synonyms:5-hydroxy-hexan-2-one;

Chemical Property of (R)-5-HYDROXY-2-HEXANONE

Chemical Property:

• Vapor Pressure: 0.0583mmHg at 25°C
• Boiling Point: 205.8oC at 760 mmHg
• Flash Point: 81.2oC
• PSA: 37.30000
• Density: 0.947g/cm3
• LogP: 0.73640

Purity/Quality:

99% ^*data from raw suppliers

(R)-5-HYDROXY-2-HEXANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-5-HYDROXY-2-HEXANONE

There total 6 articles about (R)-5-HYDROXY-2-HEXANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2,5-hexanedione (110-13-4) → (5S)-hydroxyhexane-2-one + (2R,5S)-hexanediol (38484-55-8,907567-98-0) + (2R,5R)-2,5-hexanediol (17299-07-9) + (2S,5S)-2,5-hexanediol (34338-96-0) + (5R)-hydroxyhexane-2-one (65709-73-1)

Guidance literature:

2,5-hexanedione; With Saccharomyces cerevisiae L₁₃;

In water; Reagent/catalyst; Kinetics;

DOI:10.1039/b816364b

Reference yield:

(2R,5S)-hexanediol (38484-55-8,907567-98-0) → (5R)-hydroxyhexane-2-one (65709-73-1)

Guidance literature:

With Rhodococcus ruber DSM 44541; In acetone; at 30 ℃; for 48h; pH=7.5;

DOI:10.1002/ejoc.200500839

Reference yield:

2,5-hexanedione (110-13-4) → (2R,5R)-2,5-hexanediol (17299-07-9) + (5R)-hydroxyhexane-2-one (65709-73-1)

Guidance literature:

With yeast Pichia farinosa IAM 4682 in a glucose medium; at 30 ℃; for 48h;

DOI:10.1016/0040-4020(96)00373-0

upstream raw materials:

(2R,5R)-2,5-hexanediol

2,5-hexanedione

(2R,5S)-hexanediol

5-hydroxy-hexan-2-one

Downstream raw materials:

(2R,5R)-2,5-hexanediol

(R)-5-oxohexan-2-yl ((2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-yl)carbamate

C₂₉H₃₉N₃O₆S₂

C₂₉H₄₂N₂O₇S

Refernces

• 1、 Edegger, Klaus,Stampfer, Wolfgang,Seisser, Birgit,Faber, Kurt,Mayer, Sandra F.,Oehrlein, Reinhold,Hafner, Andreas,Kroutil, Wolfgang. "Regio- and stereoselective reduction of diketones and oxidation of diols by biocatalytic hydrogen transfer". . p. 1904 - 1909. Retrieved 2007/10/03.
• 2、 Haberland, Juergen,Hummel, Werner,Daussmann, Thomas,Liese, Andreas. "New continuous production process for enantiopure (2R,5R)-hexanediol". . p. 458 - 462. Retrieved 2013/09/06.