4-methoxy-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one

Base Information

• Chemical Name: 4-methoxy-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one
• CAS No.: 16025-11-9
• Molecular Formula: C₇H₇N₃O₂S
• Molecular Weight: 197.217
• Mol file: 16025-11-9.mol

Synonyms:4-Methoxy-7H-pyrimido <4.5-b> <1.4>-thiazin-6(5H)-on;4-methoxy-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one;4-Methoxypyrimido<4,5-b>-1,4-thiazin-6-on;HMS2303I10;4-methoxy-6-oxopyrimido<4,5-b><1,4>thiazine;5H-Pyrimido(4,5-b)(1,4)thiazin-6(7H)-one,4-methoxy;

Chemical Property of 4-methoxy-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one

Chemical Property:

• Vapor Pressure: 2.65E-08mmHg at 25°C
• Melting Point: 191-193 °C (decomp)
• Boiling Point: 450.4°Cat760mmHg
• PKA: 9.68±0.20(Predicted)
• Flash Point: 226.2°C
• PSA: 92.90000
• Density: 1.421g/cm³
• LogP: 0.61450

Purity/Quality:

4-METHOXY-5H-PYRIMIDO[4,5-B][1,4]THIAZIN-6(7H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxy-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one

There total 10 articles about 4-methoxy-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methoxy-6-oxo-7-ethoxycarbonylpyrimido<4,5-b><1,4>thiazine (42083-19-2) → 4-methoxy-6-oxopyrimido<4,5-b><1,4>thiazine (16025-11-9)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1007/BF02251635

Reference yield:

(6-methoxy-5-nitro-pyrimidin-4-ylsulfanyl)-acetic acid (89792-35-8) → 4-methoxy-6-oxopyrimido<4,5-b><1,4>thiazine (16025-11-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1021/jo01031a003

Reference yield:

4-methoxy-5-amino-6-mercaptopyrimidine (40424-48-4) → 4-methoxy-6-oxopyrimido<4,5-b><1,4>thiazine (16025-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ethanol / 3 h / Heating

2: 90 percent / aq. KOH / ethanol / Heating

With potassium hydroxide; In ethanol; 1: Alkylation / 2: Decarboxylation;

DOI:10.1007/BF02251635

upstream raw materials:

mercaptoacetic acid

4-methoxy-5-amino-6-chloropyrimidine

bromoacetic acid

4-methoxy-5-amino-6-mercaptopyrimidine

Downstream raw materials:

diethyl N-methyl-N-<4-methoxy-6-oxo-5H-pyrimido<4,5-b><1,4>thiazin-7-yl>-p-aminobenzoyl-L-glutamate

4-methoxy-6-oxo-7-(4'-carboxyphenyl)amino-5H-pyrimido<4,5-b><1,4>thiazine

Refernces