1,3-Dimethyl-5,6,7,8-tetrahydroisoquinoline

Base Information

Chemical Name:1,3-Dimethyl-5,6,7,8-tetrahydroisoquinoline
CAS No.:65818-00-0
Molecular Formula:C₁₁H₁₅N
Molecular Weight:161.247
Hs Code.:
DSSTox Substance ID:DTXSID50495088
Nikkaji Number:J3.335.375H
Wikidata:Q82343017

Synonyms:1,3-Dimethyl-5,6,7,8-tetrahydroisoquinoline;65818-00-0;SCHEMBL20416971;DTXSID50495088

Suppliers and Price of 1,3-Dimethyl-5,6,7,8-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1,3-Dimethyl-5,6,7,8-tetrahydroisoquinoline

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:161.120449483
Heavy Atom Count:12
Complexity:155

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(CCCC2)C(=N1)C

Technology Process of 1,3-Dimethyl-5,6,7,8-tetrahydroisoquinoline

There total 4 articles about 1,3-Dimethyl-5,6,7,8-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: trans-(E)-diethyl-1-(2-allylcyclohexyl)-ethylideneaminooxyphosphonate

: 65818-00-0
5,6,7,8-tetrahydro-1,3-dimethylisoquinoline

: 24730-98-1
2,3,4,5,6,7-hexahydro-1-methyl-3aH-inden-2-one

: cis-1-hydroxyl-8-formyl-9-methyl-bicyclo[4,3,0]non-8⁽⁹⁾-ene

: 1-(2-allyl-cyclohexyl)-ethanone

: 1-(2-allyl-cyclohexyl)-ethanone

Guidance literature:: trans-(E)-diethyl-1-(2-allylcyclohexyl)-ethylideneaminooxyphosphonate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

With oxygen; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jo5005422

Reference yield: 6.0%

: trans-(E)-diethyl-1-(2-allylcyclohexyl)-ethylideneaminooxyacetate

: 65818-00-0
5,6,7,8-tetrahydro-1,3-dimethylisoquinoline

: cis-1-hydroxyl-8-formyl-9-methyl-bicyclo[4,3,0]non-8⁽⁹⁾-ene

: 36306-62-4
1-Acetyl-2-(2-propenyl)cyclohexane

Guidance literature:: With triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 110 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jo5005422

Reference yield:

: 36306-62-4,74272-05-2,74272-06-3,137675-95-7,137675-96-8
trans-1-Acetyl-2-(2-propenyl)cyclohexane

: 65818-00-0
5,6,7,8-tetrahydro-1,3-dimethylisoquinoline

: 1-(2-allyl-cyclohexyl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 3 h / 20 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

3.2: 5 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium acetate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo5005422