Methyl 2,2-dichloro-3-phenylbicyclo[1.1.1]pentane-1-carboxylate

Base Information

Chemical Name:Methyl 2,2-dichloro-3-phenylbicyclo[1.1.1]pentane-1-carboxylate
CAS No.:65862-03-5
Molecular Formula:C13H12Cl2O2
Molecular Weight:271.143
Hs Code.:
DSSTox Substance ID:DTXSID401173880

Synonyms:65862-03-5;DTXSID401173880;Methyl 2,2-dichloro-3-phenylbicyclo[1.1.1]pentane-1-carboxylate

Suppliers and Price of Methyl 2,2-dichloro-3-phenylbicyclo[1.1.1]pentane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methyl 2,2-dichloro-3-phenylbicyclo[1.1.1]pentane-1-carboxylate

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:270.0214350
Heavy Atom Count:17
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C12CC(C1)(C2(Cl)Cl)C3=CC=CC=C3

Technology Process of Methyl 2,2-dichloro-3-phenylbicyclo[1.1.1]pentane-1-carboxylate

There total 4 articles about Methyl 2,2-dichloro-3-phenylbicyclo[1.1.1]pentane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 30493-96-0
methyl 3-phenylbicyclo<1.1.0>butanecarboxylate

: 650-51-1
sodium trichloroacetate

: 65862-03-5
methyl 3-phenyl-2,2-dichlorobicyclo<1.1.1>pentanecarboxylate

: 83249-03-0
methyl 2-<(1-phenyl-2,2-dichlorocyclopropyl)methyl>-3,3-dichloropropenoate

Guidance literature:: In 1,1,2,2-tetrachloroethylene; diethylene glycol dimethyl ether; at 140 ℃; for 0.5h;
DOI:10.1021/jo00146a031

Reference yield:

: 227935-29-7
methyl 3-phenylcyclobutane-1-carboxylate

: 65862-03-5
methyl 3-phenyl-2,2-dichlorobicyclo<1.1.1>pentane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NBS, benzoyl peroxyde / CCl₄ / 1 h / Heating

2: 91 percent / NaH / tetrahydrofuran; methanol / 5 h / Heating

With N-Bromosuccinimide; Perbenzoic acid; sodium hydride; In tetrahydrofuran; methanol; tetrachloromethane;
DOI:10.1021/ja00311a003

Reference yield:

: 36126-39-3
methyl 3-bromo-3-phenylcyclobutane-1-carboxylate

: 65862-03-5
methyl 3-phenyl-2,2-dichlorobicyclo<1.1.1>pentane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NaH / tetrahydrofuran; methanol / 5 h / Heating

With sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1021/ja00311a003