2-[1,1'-Biphenyl]-4-yl-7-methylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-[1,1'-Biphenyl]-4-yl-7-methylimidazo[1,2-a]pyridine
• CAS No.: 65964-64-9
• Molecular Formula: C20H16N2
• Molecular Weight: 284.36
• DSSTox Substance ID: DTXSID601214456

Synonyms:SCHEMBL13325899;DTXSID601214456;AKOS002256785;65964-64-9;2-[1,1'-Biphenyl]-4-yl-7-methylimidazo[1,2-a]pyridine

Chemical Property of 2-[1,1'-Biphenyl]-4-yl-7-methylimidazo[1,2-a]pyridine

Chemical Property:

• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 284.131348519
• Heavy Atom Count: 22
• Complexity: 355

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=NC(=CN2C=C1)C3=CC=C(C=C3)C4=CC=CC=C4

Technology Process of 2-[1,1'-Biphenyl]-4-yl-7-methylimidazo[1,2-a]pyridine

There total 3 articles about 2-[1,1'-Biphenyl]-4-yl-7-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Amino-4-methylpyridine (695-34-1) + 2-Bromo-4'-phenylacetophenone (135-73-9) → 7-methyl-2-(biphenyl-4-yl)imidazo[1,2-a]pyridine (65964-64-9)

Guidance literature:

In neat (no solvent); at 25 - 30 ℃; Milling; Green chemistry;

DOI:10.1002/jhet.4164

Reference yield:

biphenyl-4-acetaldehyde (92-91-1) → 7-methyl-2-(biphenyl-4-yl)imidazo[1,2-a]pyridine (65964-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetra-N-butylammonium tribromide / tert-Amyl alcohol / 20 °C

2: tert-Amyl alcohol / 2 h / 80 °C

With tetra-N-butylammonium tribromide; In tert-Amyl alcohol;

DOI:10.1002/ejoc.201800578

Reference yield:

→ 7-methyl-2-(biphenyl-4-yl)imidazo[1,2-a]pyridine (65964-64-9)

Guidance literature:

2-Amino-4-methyl-pyridin, /BRN= 513838/;

DOI:10.1002/hlca.19780610114

upstream raw materials:

2-Amino-4-methylpyridine

2-Bromo-4'-phenylacetophenone

biphenyl-4-acetaldehyde

Downstream raw materials:

2-biphenyl-4-yl-7-(trans-2-dibenzofuran-3-yl-vinyl)-imidazo[1,2-a]pyridine

(2-biphenyl-4-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol

7-(trans-2-benzo[1,3]dioxol-5-yl-vinyl)-2-biphenyl-4-yl-imidazo[1,2-a]pyridine

2-biphenyl-4-yl-7-(trans-2-thiophen-2-yl-vinyl)-imidazo[1,2-a]pyridine

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