L-Phenylalanyl azide, N-[N-[(phenylmethoxy)carbonyl]glycyl]-

Base Information

• Chemical Name: L-Phenylalanyl azide, N-[N-[(phenylmethoxy)carbonyl]glycyl]-
• CAS No.: 66012-29-1
• Molecular Formula: C₁₉H₁₉N₅O₄
• Molecular Weight: 381.391
• Mol file: 66012-29-1.mol

Synonyms:

Chemical Property of L-Phenylalanyl azide, N-[N-[(phenylmethoxy)carbonyl]glycyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Phenylalanyl azide, N-[N-[(phenylmethoxy)carbonyl]glycyl]-

There total 1 articles about L-Phenylalanyl azide, N-[N-[(phenylmethoxy)carbonyl]glycyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-glycylphenylalanyl hydrazide (17942-42-6) → Z-Gly-L-Phe-N3 (66012-29-1)

Guidance literature:

With hydrogenchloride; isopentyl nitrite; In 1,4-dioxane; N,N-dimethyl-formamide; at -20 ℃; for 0.0833333h;

DOI:10.1248/cpb.28.310

Reference yield:

Z-Gly-L-Phe-N3 (66012-29-1) → Gly-L-Phe-Ser-Pro (23827-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dioxane; H₂O / 48 h / 4 °C / pH 8

2: 48.6 percent / H₂ / Pd / methanol

With hydrogen; triethylamine; palladium; In 1,4-dioxane; methanol; water;

DOI:10.1248/cpb.28.310

Reference yield:

serine-proline (23827-93-2) + Z-Gly-L-Phe-N3 (66012-29-1) → Z-Gly-L-Phe-Ser-Pro-OH (23827-98-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 4 ℃; for 48h; Yield given; pH 8;

DOI:10.1248/cpb.28.310

upstream raw materials:

Cbz-glycylphenylalanyl hydrazide

Downstream raw materials:

Z-Gly-L-Phe-Ser-Pro-OH

Gly-L-Phe-Ser-Pro

Refernces