2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:66040-36-6
Molecular Formula:C24H23NO3
Molecular Weight:373.452
Hs Code.:
DSSTox Substance ID:DTXSID101151502
ChEMBL ID:CHEMBL1729817

Synonyms:66040-36-6;Methanone, (3,4-dihydro-6,7-dimethoxy-1-phenyl-2(1H)-isoquinolinyl)phenyl-;Oprea1_481432;MLS000974894;CHEMBL1729817;DTXSID101151502;HMS2824H22;STK724464;AKOS001363376;AKOS016088662;SMR000497638;Z27282401;2-benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline;(3,4-Dihydro-6,7-dimethoxy-1-phenyl-2(1H)-isoquinolinyl)phenylmethanone;(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone;[6,7-dimethoxy-1-phenyl-3,4-dihydro-2(1H)-isoquinolinyl](phenyl)methanone

Suppliers and Price of 2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:373.16779360
Heavy Atom Count:28
Complexity:512

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C2C(N(CCC2=C1)C(=O)C3=CC=CC=C3)C4=CC=CC=C4)OC

Technology Process of 2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 2-Benzoyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1333162-61-0
N-(2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethyl)benzamide

: 66040-36-6
(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.3390/molecules16087019

Reference yield:

: 67616-16-4
N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide

: 66040-36-6
(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: polyphosphoric acid / dichloromethane / 2 h / 80 °C

2: methanol; sodium tetrahydroborate / 0.5 h / 20 °C

3: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; toluene-4-sulfonic acid; In dichloromethane; 1: Friedel Crafts acylation;
DOI:10.3390/molecules16087019

Reference yield:

: 2'-(2-benzamidoethyl)-4',5'-dimethoxybenzophenone

: 66040-36-6
(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / 0.5 h / 20 °C

2: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.3390/molecules16087019