(+)-Integerrinecic acid

Base Information

Chemical Name:(+)-Integerrinecic acid
CAS No.:469-45-4
Molecular Formula:C₁₀H₁₆O₅
Molecular Weight:216.234
Hs Code.:
Mol file:469-45-4.mol

Synonyms:(+)-Integerrinecic acid;(R-(R*,R*-(E)))-5-ethylidene-2-hydroxy-2,3-dimethylhexanedioic acid;Hexanedioic acid, 5-ethylidene-2-hydroxy-2,3-dimethyl-, (R-(R*,R*-(E)))-;469-45-4

Suppliers and Price of (+)-Integerrinecic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (+)-Integerrinecic acid

Chemical Property:

Vapor Pressure:1.13E-10mmHg at 25°C
Boiling Point:466.7°Cat760mmHg
Flash Point:250.2°C
PSA：94.83000
Density:1.241g/cm³
LogP:0.87910
XLogP3:0.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:216.09977361
Heavy Atom Count:15
Complexity:294

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC=C(CC(C)C(C)(C(=O)O)O)C(=O)O
Isomeric SMILES:C/C=C(\C[C@@H](C)[C@](C)(C(=O)O)O)/C(=O)O

Technology Process of (+)-Integerrinecic acid

There total 15 articles about (+)-Integerrinecic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 520-65-0
rosmarinine

: 469-45-4,6582-63-4,6703-97-5,6883-40-5,10407-68-8,10407-69-9,10407-70-2,10407-71-3,10407-73-5,13588-16-4,86747-28-6,86747-29-7
Senecinsaeure

: 520-61-6
(-)-Rosmarinecine

Guidance literature:: With barium dihydroxide;

Reference yield:

: 81165-20-0
(2R,3R)-5-(1-Hydroxy-ethyl)-2,3-dimethyl-6-oxo-tetrahydro-pyran-2-carboxylic acid methyl ester

: 469-45-4,6582-63-4,6703-97-5,6883-40-5,10407-68-8,10407-69-9,10407-70-2,10407-71-3,10407-73-5,13588-16-4,86747-28-6,86747-29-7
(+/-)-integerrinecic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, 2-fluoro-1-methylpyridinium p-toluenesulfonate / CH₂Cl₂

2: 96 percent / LiOH*H₂O / tetrahydrofuran / 0 °C

3: strong alkali

With lithium hydroxide; strong alkali; 1-methyl-2-fluoropyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00322a036

Reference yield:

: 81165-19-7,105927-22-8
5-methoxycarbonyl-4,5-cis-dimethyl-5-peantanolide

: 469-45-4,6582-63-4,6703-97-5,6883-40-5,10407-68-8,10407-69-9,10407-70-2,10407-71-3,10407-73-5,13588-16-4,86747-28-6,86747-29-7
(+/-)-integerrinecic acid

Guidance literature:: Multi-step reaction with 4 steps

1: BuLi, diisopropylamine / tetrahydrofuran; hexane / 1 h / -40 - -30 °C

2: Et₃N, 2-fluoro-1-methylpyridinium p-toluenesulfonate / CH₂Cl₂

3: 96 percent / LiOH*H₂O / tetrahydrofuran / 0 °C

4: strong alkali

With lithium hydroxide; n-butyllithium; strong alkali; 1-methyl-2-fluoropyridinium p-toluenesulfonate; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00322a036