Technology Process of 6,8a-dimethyl-4,6,8,8a-tetrahydro-7H-[1,3]thiazolo[4,5-e]indol-7-one
There total 6 articles about 6,8a-dimethyl-4,6,8,8a-tetrahydro-7H-[1,3]thiazolo[4,5-e]indol-7-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
toluene;
for 4h;
Heating;
DOI:10.1248/cpb.30.4378
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Br2, 48percent HBr / 1.) AcOH, ice-cooling, 30 min, 2.) THF, reflux, 4 h
2: 1.) NaNO2, 40percent H2SO4; 2.) CuSO4.5H2O, NaCl / 1.) water, -12 deg C, 2 h; 2.) water, -2 deg C, 2 h, room temperature
3: 98 percent / hydrogen chloride / ice-cooling
4: 99 percent / H2, triethylamine / 10percent Pd-C / ethanol
5: 78 percent / methanol
6: 88 percent / p-TsOH / toluene / 4 h / Heating
With
hydrogenchloride; sulfuric acid; hydrogen bromide; hydrogen; bromine; toluene-4-sulfonic acid; copper(II) sulfate; triethylamine; sodium chloride; sodium nitrite;
palladium on activated charcoal;
In
methanol; ethanol; toluene;
DOI:10.1248/cpb.30.4378
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaNO2, 40percent H2SO4; 2.) CuSO4.5H2O, NaCl / 1.) water, -12 deg C, 2 h; 2.) water, -2 deg C, 2 h, room temperature
2: 98 percent / hydrogen chloride / ice-cooling
3: 99 percent / H2, triethylamine / 10percent Pd-C / ethanol
4: 78 percent / methanol
5: 88 percent / p-TsOH / toluene / 4 h / Heating
With
hydrogenchloride; sulfuric acid; hydrogen; toluene-4-sulfonic acid; copper(II) sulfate; triethylamine; sodium chloride; sodium nitrite;
palladium on activated charcoal;
In
methanol; ethanol; toluene;
DOI:10.1248/cpb.30.4378
