(1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride

Base Information

• Chemical Name: (1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride
• CAS No.: 65481-69-8
• Molecular Formula: C7H13 N . Cl H
• Molecular Weight: 147.648
• European Community (EC) Number: 265-790-3
• Mol file: 65481-69-8.mol

Synonyms:(1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride;65481-69-8;121055-08-1;Bicyclo[2.2.1]heptan-2-amine, hydrochloride, endo-;Endo-bicyclo[2.2.1]heptan-2-amine hydrochloride;rac-(1S,2R,4R)-Bicyclo[2.2.1]hept-2-ylamine hydrochloride;SCHEMBL541716;ENDO-2-AMINONORBORNANE HCL;MFCD00062334;AT24376;AT24387;AS-83169;CS-0120246;CS-0526930;NS00087826;EN300-7434946;EN300-37429942;(1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine HCl;(1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine;hydrochloride;rac-(1R,2S,4S)-bicyclo[2.2.1]heptan-2-amine hydrochloride;rel-(1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride

Chemical Property of (1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride

Chemical Property:

• Vapor Pressure: 0.233mmHg at 25°C
• Melting Point: 295 °C (dec.)(lit.)
• Boiling Point: 203.4°C at 760 mmHg
• Flash Point: 76.8°C
• PSA: 26.02000
• LogP: 2.63600
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 147.0814771
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

Endo-bicyclo[2.2.1]heptan-2-aminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC2CC1CC2N.Cl
• Isomeric SMILES: C1C[C@H]2C[C@@H]1C[C@H]2N.Cl

Technology Process of (1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride

There total 6 articles about (1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

diethyl N-exo-norbornylphosphoramidate (85231-79-4) → (+/-)-exo-2-aminonorbornane hydrochloride (14370-45-7,39245-79-9,65481-69-8,111058-85-6,121055-08-1,121122-83-6,142344-61-4)

Guidance literature:

With hydrogenchloride; In benzene; Ambient temperature;

DOI:10.1055/s-1982-29995

Reference yield: 42.0%

bicyclo[2.2.1]heptan-2-one oxime (4576-48-1,49805-50-7,49805-51-8,141782-05-0) → (1R,4S)-Bicyclo[2.2.1]heptan-2-ol (497-36-9,497-37-0,1632-68-4,24325-44-8,29583-34-4,36779-79-0,60133-16-6,61277-90-5,61277-93-8) + (±)-endo-2-norbornylamine hydrochloride (14370-45-7,39245-79-9,65481-69-8,111058-85-6,121055-08-1,121122-83-6,142344-61-4)

Guidance literature:

bicyclo[2.2.1]heptan-2-one oxime; With NiAl₂; potassium hydroxide; In tetrahydrofuran; water; Reflux;

With hydrogenchloride; In tetrahydrofuran; tert-butyl methyl ether;

DOI:10.1134/S1070428019110162

Reference yield:

bicyclo(2.2.1)heptane-2-endo-carboxylic acid (934-28-1) → bicyclo[2.2.1]heptan-2-endo-amine hydrochloride (65481-69-8)

Guidance literature:

Yield given. Multistep reaction;

upstream raw materials:

acide bicyclo<2.2.1>heptane carboxylique-2 exo

diethyl N-exo-norbornylphosphoramidate

norborn-2-ene

bicyclo(2.2.1)heptane-2-endo-carboxylic acid

Downstream raw materials:

N-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl-guanidine

N-(exo-norborn-2-yl)-N'-(2-iodophenyl)guanidine

endo-2-Dimethylamino-norbornan

endo-2-nitronorbornane