1H-Pyrrole, 1-(trifluoroacetyl)- (9CI)

Base Information

• Chemical Name: 1H-Pyrrole, 1-(trifluoroacetyl)- (9CI)
• CAS No.: 66399-79-9
• Molecular Formula: C6H4F3NO
• Molecular Weight: 163.099
• Hs Code.: 2933990090
• Mol file: 66399-79-9.mol

Synonyms:1-trifluoroacetyl-pyrrole;trifluoroacetylpyrrole;N-Trifluoracetylpyrrol;

Chemical Property of 1H-Pyrrole, 1-(trifluoroacetyl)- (9CI)

Chemical Property:

• PSA: 22.00000
• LogP: 1.69060

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole, 1-(trifluoroacetyl)- (9CI)

There total 2 articles about 1H-Pyrrole, 1-(trifluoroacetyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

pyrrole (109-97-7,30604-81-0) → N-(trifluoroacetyl)pyrrole (66399-79-9)

Guidance literature:

With trifluoroacetic anhydride; In benzene;

Reference yield: 30.0%

sodium pyrrolide (7697-45-2) + trifluoroacetic anhydride (407-25-0) → N-(trifluoroacetyl)pyrrole (66399-79-9)

Guidance literature:

In diethyl ether; for 0.333333h;

DOI:10.1021/ja00406a034

Reference yield:

N-(trifluoroacetyl)pyrrole (66399-79-9) → pyrrole (109-97-7,30604-81-0) + trifluoroacetic acid (76-05-1)

Guidance literature:

With hydrogenchloride; In water; at 25 ℃; Rate constant; Mechanism; hydration and hydrolysis; hydrolysis catalyzed chloroacetic or phosphoric acid; acid-catalyzed hydrolyses of acylpyrroles and acylindoles, solvent hydrogen isotope effect, salt effect;

DOI:10.1021/ja00406a034

upstream raw materials:

sodium pyrrolide

trifluoroacetic anhydride

pyrrole

Downstream raw materials:

pyrrole

trifluoroacetic acid

Refernces

• 1、 Cipiciany, Antonio,Linda, Paolo,Savelli, Gianfranco,Bunton, Clifford A.. "Acid-Catalyzed Hydrolyses of Acylpyrroles and Acylindoles. Noninvolvement of Protonated Substrates". . p. 4874 - 4879. Retrieved 2007/10/02.