Technology Process of Imidazo[4,5-d][1,3]diazepine,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(1S,3R)-3-[[[(1,1-dimethylethyl
)diphenylsilyl]oxy]methyl]cyclopentyl]-3,4,7,8-tetrahydro-, (8R)-
There total 9 articles about Imidazo[4,5-d][1,3]diazepine,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(1S,3R)-3-[[[(1,1-dimethylethyl
)diphenylsilyl]oxy]methyl]cyclopentyl]-3,4,7,8-tetrahydro-, (8R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,2-propanedithiol; triethylamine;
In
methanol;
at 50 ℃;
for 13h;
DOI:10.1248/cpb.51.1153
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / H2 / Pt/C / methanol / 24 h / 20 °C / 775.72 Torr
2: 2.9 g / NaBH4 / methanol / 3 h / 20 °C
3: imidazole / dimethylformamide / 18 h / 20 °C
4: 1.4 g / HCl / ethyl acetate / 12 h
5: 1,2-dichloro-ethane; 2,2,2-trifluoro-ethanol / 4 h / 80 °C
6: 510 mg / 13 h / 80 °C
7: 67 percent / Et3N; propanedithiol / methanol / 13 h / 50 °C
With
1H-imidazole; hydrogenchloride; sodium tetrahydroborate; 1,2-propanedithiol; hydrogen; triethylamine;
platinum on activated charcoal;
In
methanol; 2,2,2-trifluoroethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.51.1153
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aq. LiOH / methanol; tetrahydrofuran / 4 h / 20 °C
1.2: 95 percent / Ac2O; NaOAc / 18 h / Heating
2.1: 97 percent / H2 / Pt/C / methanol / 24 h / 20 °C / 775.72 Torr
3.1: 2.9 g / NaBH4 / methanol / 3 h / 20 °C
4.1: imidazole / dimethylformamide / 18 h / 20 °C
5.1: 1.4 g / HCl / ethyl acetate / 12 h
6.1: 1,2-dichloro-ethane; 2,2,2-trifluoro-ethanol / 4 h / 80 °C
7.1: 510 mg / 13 h / 80 °C
8.1: 67 percent / Et3N; propanedithiol / methanol / 13 h / 50 °C
With
1H-imidazole; hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; 1,2-propanedithiol; hydrogen; triethylamine;
platinum on activated charcoal;
In
tetrahydrofuran; methanol; 2,2,2-trifluoroethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.51.1153
![4-[(1R)-2-azido-1-[(tert-butyldimethylsilyl)oxy]ethyl]-1-[3-(tert-butyldiphenylsilyl)oxy]methyl-cyclopentyl-5-[(dimethylaminomethylene)amino]-imidazole](/Databaselist/images/loading.webp)
