1-Pyrrolidinecarboxylic acid, 4-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2-[[[(4-methylphen yl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 4-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2-[[[(4-methylphen yl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2R,4R)-
CAS No.:664966-95-4
Molecular Formula:C22H29N3O7S
Molecular Weight:479.554
Hs Code.:

1-Pyrrolidinecarboxylic acid,
4-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2-[[[(4-methylphen
yl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2R,4R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 4-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2-[[[(4-methylphen yl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2R,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 4-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2-[[[(4-methylphen yl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2R,4R)-

There total 3 articles about 1-Pyrrolidinecarboxylic acid, 4-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2-[[[(4-methylphen yl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 98-59-9
p-toluenesulfonyl chloride

: 320727-40-0
N-(tert-butoxycarbonyl)-cis-4'-(thymin-1-yl)-D-prolinol

: 664966-95-4
N-(tert-butoxycarbonyl)-cis-4'-(thymin-1-yl)-D-prolinol p-toluenesulfonate

Guidance literature:: With pyridine; at 20 ℃; for 18h;
DOI:10.1039/b306156f

Reference yield:

: 320727-38-6
cis-4'-(N³-benzoylthymin-1-yl)-N-(tert-butoxycarbonyl)-D-proline ethyl ester

: 664966-95-4
N-(tert-butoxycarbonyl)-cis-4'-(thymin-1-yl)-D-prolinol p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

2: 99 percent / pyridine / 18 h / 20 °C

With pyridine; lithium borohydride; In tetrahydrofuran;
DOI:10.1039/b306156f

Reference yield:

: 664967-07-1
N-(tert-butoxycarbonyl)-trans-4-formyloxy-D-proline ethyl ester

: 664966-95-4
N-(tert-butoxycarbonyl)-cis-4'-(thymin-1-yl)-D-prolinol p-toluenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / aq. NH₃ / methanol / 5 h / 20 °C

2: 62 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 18 h / 20 °C

3: 69 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

4: 99 percent / pyridine / 18 h / 20 °C

With pyridine; ammonium hydroxide; lithium borohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1039/b306156f