1-Dodecene, 1-iodo-, (1E)-

Base Information

• Chemical Name: 1-Dodecene, 1-iodo-, (1E)-
• CAS No.: 66553-46-6
• Molecular Formula: C12H23I
• Molecular Weight: 294.219
• Mol file: 66553-46-6.mol

Synonyms:

Chemical Property of 1-Dodecene, 1-iodo-, (1E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Refernces

Homogeneous catalytic aminocarbonylation of 1-iodo-1-dodecene. The facile synthesis of odd-number carboxamides via palladium-catalysed aminocarbonylation

10.1016/j.tet.2008.08.022

This research investigates the synthesis of odd-number carboxamides through palladium-catalysed aminocarbonylation of (E)- and (Z)-1-iodo-1-dodecene. The study aims to extend the scope of aminocarbonylation to open-chain iodoalkenes, which are easily accessible from even-number aldehydes, to produce odd-number linear carboxamides that are less common in nature. Key chemicals used include various amine nucleophiles such as tert-butylamine, piperidine, morpholine, and glycine methyl ester, along with the iodoalkene substrate synthesised from 1-dodecanal via a hydrazone intermediate. The reactions were performed under atmospheric and high-pressure carbon monoxide conditions using palladium(II) acetate and triphenylphosphine as catalysts. The study concludes that the chemoselectivity of the reaction towards forming conjugated unsaturated carboxamides or alkyne-type amides depends on factors like the type of amine used and carbon monoxide pressure. The findings provide an efficient method for functionalising open-chain iodoalkenes and offer a straightforward route to synthesise higher carboxamides from readily available aldehydes, contributing to the field of synthetic chemistry and potentially aiding in the development of new pharmaceuticals and materials.