Sulfoximide

Base Information

• Chemical Name: Sulfoximide
• CAS No.: 14616-60-5
• Molecular Formula: H₃NOS
• Molecular Weight: 65.0959
• Mol file: 14616-60-5.mol

Synonyms:Sulfilimine,S-oxide

Chemical Property of Sulfoximide

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Sulfoximide

There total 2 articles about Sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ sulfonyl imine (14616-60-5)

Guidance literature:

Reference yield:

→ sulfonyl imine (14616-60-5) + sulfoximine anion

Guidance literature:

Refernces

Asymmetric decarboxylative claisen rearrangement reactions of sulfoximine-substituted allylic tosylacetic esters

10.1021/jo050747d

The research explores the development of an asymmetric version of the decarboxylative Claisen rearrangement (dCr) reaction using sulfoximine-substituted allylic acetate esters. The purpose of the study is to achieve high diastereoselectivity in the dCr reaction by introducing chiral sulfoximines as surrogates for sulfones. The researchers synthesized various esters containing N-arylsulfonyl sulfoximines and subjected them to the dCr reaction, achieving diastereoselectivities up to 82:18. Key chemicals used include N-(2,4,6-triisopropylphenylsulfonyl)-S-phenyl sulfoximine, which provided the best selectivity, and reagents like N,O-bis(trimethylsilyl)acetamide (BSA) and potassium acetate (KOAc) for facilitating the reaction. The study concludes that the stereochemical outcome of the rearrangement can be rationalized by a pseudochair transition-state model, with the stereochemistry of the major isomers confirmed by X-ray crystallography. The results suggest that further modifications to the system, such as adding more electron-withdrawing groups, could enhance selectivity and lower reaction temperatures.