3-FLUORO-DL-TYROSINE

Base Information

• Chemical Name: 3-FLUORO-DL-TYROSINE
• CAS No.: 139-26-4
• Molecular Formula: C₉H₁₀FNO₃
• Molecular Weight: 199.182
• Mol file: 139-26-4.mol

Synonyms:DL-Tyrosine,3-fluoro-; Tyrosine, 3-fluoro-, DL- (8CI); 3-Fluoro-DL-tyrosine;3-Fluorotyrosine; Ba 2745; DL-3-Fluorotyrosin; DL-3-Fluorotyrosine;DL-m-Fluorotyrosine; Fluorthyrin; NSC 83231; Pardinon; m-Fluoro-DL-tyrosine

Chemical Property of 3-FLUORO-DL-TYROSINE

Chemical Property:

• Vapor Pressure: 4.89E-07mmHg at 25°C
• Melting Point: 280 °C (dec.)(lit.)
• Boiling Point: 362.4 °C at 760 mmHg
• Flash Point: 172.9 °C
• PSA: 83.55000
• Density: 1.421 g/cm³
• LogP: 1.18600
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoro-DL-tyrosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-DL-TYROSINE

There total 5 articles about 3-FLUORO-DL-TYROSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(trifluoroacetyl)-3-fluoro-L-tyrosine methyl ester (73210-53-4) → 3-fluoro-L-tyrosine (139-26-4)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1021/jo01298a058

Reference yield:

L-tyrosine methyl ester HCl (3417-91-2) → 3-fluoro-L-tyrosine (139-26-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 2 h / Ambient temperature

2: fuming nitric acid / acetic acid / 1) 10 deg C, 1 h, 2) r.t., 1 h

3: H₂ / PtO₂ / ethanol / 2 h

4: 1) NaNO₂, 50percent HBF₄ / 1) water, 2 h, 2) irradiation, 3 h

5: 70 percent / 6N HCl / Heating

With hydrogenchloride; tetrafluoroboric acid; hydrogen; nitric acid; sodium nitrite; platinum(IV) oxide; In ethanol; acetic acid;

DOI:10.1021/jo01298a058

Reference yield:

N-(trifluoroacetyl)-3-nitro-L-tyrosine methyl ester (5106-00-3) → 3-fluoro-L-tyrosine (139-26-4)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / PtO₂ / ethanol / 2 h

2: 1) NaNO₂, 50percent HBF₄ / 1) water, 2 h, 2) irradiation, 3 h

3: 70 percent / 6N HCl / Heating

With hydrogenchloride; tetrafluoroboric acid; hydrogen; sodium nitrite; platinum(IV) oxide; In ethanol;

DOI:10.1021/jo01298a058

upstream raw materials:

N-(trifluoroacetyl)-3-fluoro-L-tyrosine methyl ester

L-tyrosine methyl ester HCl

3-(3-Amino-4-hydroxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

N-(trifluoroacetyl)-3-nitro-L-tyrosine methyl ester