4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride

Base Information

• Chemical Name: 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
• CAS No.: 666261-01-4
• Molecular Formula: C6H13NO2.ClH
• Molecular Weight: 167.636
• Hs Code.: 2932999099
• Mol file: 666261-01-4.mol

Synonyms:4-(aminomethyl)oxan-4-ol,hydrochloride;

Chemical Property of 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride

Chemical Property:

• PSA: 55.48000
• LogP: 0.98890
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Aminomethyltetrahydro-4H-pyran-4-olHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride

There total 3 articles about 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Trimethylsilanyloxy-tetrahydro-pyran-4-carbonitrile (112799-02-7) → 4-(aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride (666261-01-4)

Guidance literature:

4-Trimethylsilanyloxy-tetrahydro-pyran-4-carbonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 4h;

With potassium fluoride; sodium sulfate; In tetrahydrofuran; toluene; at 0 ℃;

With hydrogenchloride; In tetrahydrofuran; ethyl acetate; toluene;

Reference yield:

4-hydroxy-tetrahydropyran-4-carbonitrile (50289-10-6) → 4-(aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride (666261-01-4)

Guidance literature:

4-hydroxy-tetrahydropyran-4-carbonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → 4-(aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride (666261-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc(II) iodide / toluene / 0.25 h / 20 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 70 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; zinc(II) iodide; In tetrahydrofuran; toluene;

upstream raw materials:

4-hydroxy-tetrahydropyran-4-carbonitrile

4-Trimethylsilanyloxy-tetrahydro-pyran-4-carbonitrile

Tetrahydro-4H-pyran-4-one

Downstream raw materials:

(2S,4S,5S,7S)-5-azido-4-(tert-butyl-dimethyl-silanyloxy)-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (4-hydroxy-tetrahydro-pyran-4-ylmethyl)-amide