Isopropyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

Base Information

Chemical Name:Isopropyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate
CAS No.:66635-71-0
Molecular Formula:C11H15NO2
Molecular Weight:193.246
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60510099

Synonyms:66635-71-0;ISOPROPYL 2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLATE;SCHEMBL9381071;DTXSID60510099;Propan-2-yl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

Suppliers and Price of Isopropyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Isopropyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

Chemical Property:

Boiling Point:283.6±23.0 °C(Predicted)
PKA:-2.88±0.40(Predicted)
PSA：31.23000
Density:1.16±0.1 g/cm3(Predicted)
LogP:1.92700
XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:193.110278721
Heavy Atom Count:14
Complexity:227

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)OC(=O)C1CCN2C1=CC=C2

Technology Process of Isopropyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

There total 9 articles about Isopropyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 66635-70-9
isopropyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate-7-carboxylic acid

: 66635-71-0
i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

Guidance literature:: at 270 ℃; for 1h;
DOI:10.1139/v82-328

Reference yield:

: 123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6
1,4-dioxane

: 66635-70-9
isopropyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate-7-carboxylic acid

: 66635-71-0
i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

Guidance literature:: With acetic acid; In acetone; benzene;

Reference yield:

: 66635-68-5
dimethyl 1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1,7-dicarboxylate

: 66635-71-0
i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 85percent KOH / methanol; H₂O / 3 h / Heating

2: 91 percent / HCl / 1.5 h / 0 -> 25 deg C

3: 68 percent / 1 h / 270 °C

With hydrogenchloride; potassium hydroxide; In methanol; water;
DOI:10.1139/v82-328