Phosphinic acid, diphenyl-, 4-formylphenyl ester

Base Information

• Chemical Name: Phosphinic acid, diphenyl-, 4-formylphenyl ester
• CAS No.: 66667-06-9
• Molecular Formula: C19H15O3P
• Molecular Weight: 322.3
• Mol file: 66667-06-9.mol

Synonyms:

Chemical Property of Phosphinic acid, diphenyl-, 4-formylphenyl ester

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphinic acid, diphenyl-, 4-formylphenyl ester

There total 3 articles about Phosphinic acid, diphenyl-, 4-formylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + Diphenylphosphine oxide (4559-70-0) → 4-formylphenyl diphenylphosphinate (66667-06-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; potassium iodide; In acetonitrile; at 20 ℃; for 3h; Electrolysis;

DOI:10.1039/c9cc01378d

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + Diphenylphosphinic chloride (1499-21-4) → 4-formylphenyl diphenylphosphinate (66667-06-9)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃;

DOI:10.1021/jo061308x

Reference yield:

4-nitrophenyl diphenylphosphinate (10259-20-8) + 4-formylphenoxide ion (18938-17-5) → p-nitrophenolate (14609-74-6) + 4-formylphenyl diphenylphosphinate (66667-06-9)

Guidance literature:

In water; dimethyl sulfoxide; at 25 ℃; Rate constant;

DOI:10.1039/c39930000109

upstream raw materials:

4-nitrophenyl diphenylphosphinate

4-formylphenoxide ion

4-hydroxy-benzaldehyde

Diphenylphosphinic chloride

Downstream raw materials:

ethyl diphenylphosphinate

4-hydroxybenzaldehyde potassium salt

4-formylphenoxide ion

O-4-chlorophenyl diphenylphosphinate

Refernces

• 1、 Seki, Hajime,Xue, Song,Pellett, Sabine,?ilhár, Peter,Johnson, Eric A.,Janda, Kim D.. "Cellular protection of SNAP-25 against botulinum neurotoxin/A: Inhibition of thioredoxin reductase through a suicide substrate mechanism". supporting information. p. 5568 - 5575. Retrieved 2016/06/01.
• 2、 Hong, Hyo-Jeong,Lee, Jieun,Bae, Ae Ri,Um, Ik-Hwan. "Kinetics and reaction mechanism for alkaline hydrolysis of Y-substituted-phenyl diphenylphosphinates". . p. 2001 - 2005. Retrieved 2013/09/02.