2-amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide

Base Information

• Chemical Name: 2-amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide
• CAS No.: 23380-54-3
• Molecular Formula: C14H14 Cl N3 O3 S
• Molecular Weight: 339.802
• Hs Code.: 2935009090
• European Community (EC) Number: 245-620-4
• UNII: U9363D8R2T
• DSSTox Substance ID: DTXSID80177941
• Nikkaji Number: J228.945H
• Wikidata: Q27290937
• Mol file: 23380-54-3.mol

Synonyms:23380-54-3;2-amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide;EINECS 245-620-4;2-Amino-5-(aminosulphonyl)-4-chloro-N-(o-tolyl)benzamide;UNII-U9363D8R2T;U9363D8R2T;SCHEMBL11246918;DTXSID80177941;2-AMINO-5-(AMINOSULFONYL)-4-CHLORO-N-(O-TOLYL)BENZAMIDE;Metolazone benzamide analog [USP Impurity];METOLAZONE IMPURITY E [EP IMPURITY];2-Amino-4-chloro-5-sulfamoyl-N-(o-tolyl)benzamide;2-AMINO-4-CHLORO-5-SULFAMOYL-O-BENZOTOLUIDIDE;Q27290937;2-Amino-5-aminosulfonyl-4-chloro-N-(2-methylphenyl)benzamide;Benzamide, 2-amino-5-(aminosulfonyl)-4-chloro-N-(2-methylphenyl)-

Chemical Property of 2-amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide

Chemical Property:

• Melting Point: 289-292 °C (decomp)
• Boiling Point: °Cat760mmHg
• PKA: 9.38±0.60(Predicted)
• Flash Point: °C
• PSA: 127.15000
• Density: 1.491g/cm³
• LogP: 4.87660
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 339.0444402
• Heavy Atom Count: 22
• Complexity: 508

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1NC(=O)C2=CC(=C(C=C2N)Cl)S(=O)(=O)N
• Uses: 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide is an intermediate in the synthesis of Metolazone (M338750); a diuretic and antihypertensive agent.

Technology Process of 2-amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide

There total 1 articles about 2-amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-amino-5-(aminosulfonyl)-4-chloro-N-(o-tolyl)benzamide (23380-54-3)

Guidance literature:

6-Chlor-7-sulfamylisatinsaeureanhydrid, o-Toluidin;

DOI:10.1021/jm00299a022