Technology Process of 4-[[(3aS,4S,9R,9aR)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-6,7-dimethoxy-1-oxo-3a,4,9,9a-tetrahydro-3H-benzo[f]isobenzofuran-4-yl]amino]benzonitrile
There total 4 articles about 4-[[(3aS,4S,9R,9aR)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-6,7-dimethoxy-1-oxo-3a,4,9,9a-tetrahydro-3H-benzo[f]isobenzofuran-4-yl]amino]benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6,7-O,O-demethylene-6,7-O,O-dimethylpodophyllotoxin;
With
trimethylsilyl iodide;
In
1,2-dichloro-ethane;
at -20 - -10 ℃;
for 6h;
4-Aminobenzonitrile;
With
barium carbonate;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12h;
DOI:10.1016/j.bmc.2004.04.048
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / boron trichloride / CH2Cl2 / 1 h / -70 - -65 °C
2: 94 percent / diethyl ether; methanol / 3 h / Ambient temperature
3: 1.) HBr, 2.) barium carbonate / 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight
With
hydrogen bromide; boron trichloride; barium carbonate;
In
methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00083a010
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 94 percent / diethyl ether; methanol / 3 h / Ambient temperature
2: 1.) HBr, 2.) barium carbonate / 1.) dichloromethane, RT, 14 h, 2.) 1,2-dichloroethane, RT, overnight
With
hydrogen bromide; barium carbonate;
In
methanol; diethyl ether;
DOI:10.1021/jm00083a010
