Arg-3-hyp-7-phe-bradykinin

Base Information

• Chemical Name: Arg-3-hyp-7-phe-bradykinin
• CAS No.: 109333-26-8
• Molecular Formula: C60H87 N19 O13
• Molecular Weight: 1282.47
• UNII: DV64B0PLEH
• Nikkaji Number: J380.533F
• Wikidata: Q27088026
• Metabolomics Workbench ID: 66350
• ChEMBL ID: CHEMBL446325
• Mol file: 109333-26-8.mol

Synonyms:Arg-3-Hyp-7-Phe-bradykinin;bradykinin, Arg(0)-Hyp(3)-Phe(7)-;bradykinin, Arg-Hyp(3)-Phe(7)-;bradykinin, arginyl-hydroxyprolyl(3)-phenylalanine(7)-;NPC 567;NPC-567

Chemical Property of Arg-3-hyp-7-phe-bradykinin

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 533.80000
• Density: 1.48g/cm³
• LogP: 1.77150
• Storage Temp.: −20°C
• XLogP3: -5.9
• Hydrogen Bond Donor Count: 17
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 36
• Exact Mass: 1281.67307391
• Heavy Atom Count: 92
• Complexity: 2550

Purity/Quality:

98%min ^*data from raw suppliers

(D-Arg0, Hyp 3,D-Phe7)-Bradykinin trifluoroacetate salt H-D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH trifluoroacetate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(N(C1)C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)C(=O)N2CC(CC2C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(=O)O)O
• Isomeric SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)N)C(=O)N2C[C@@H](C[C@H]2C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N[C@H](CC4=CC=CC=C4)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)O

Technology Process of Arg-3-hyp-7-phe-bradykinin

There total 1 articles about Arg-3-hyp-7-phe-bradykinin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (40350-83-2,54631-82-2,54631-81-1) + Boc-L-Arg(Tos)-OH + Boc-D-Arg(Tos)-OH → NPC 567 (109333-26-8)

Guidance literature:

Multistep reaction;

DOI:10.1021/jm00087a010

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

(2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Refernces