Piperazine, 1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]acetyl]-

Base Information

Chemical Name:Piperazine, 1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]acetyl]-
CAS No.:666752-84-7
Molecular Formula:C20H25F2N5O3S2
Molecular Weight:485.579
Hs Code.:

Synonyms:

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Chemical Property of Piperazine, 1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]acetyl]-

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Technology Process of Piperazine, 1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]acetyl]-

There total 3 articles about Piperazine, 1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-1,4-dihydro-6-[[(1R)-2-hydroxy-1- methylethyl]amino]-4-oxo-5-pyrimidinyl]thio]acetyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-85-0
piperazine

: 666752-81-4
ethyl [[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetate

: 666752-84-7
1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetyl]piperazine

Guidance literature:: In methanol; at 40 ℃; for 20h;

Reference yield:

: 666752-67-6
2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-4-pyrimidinol

: 666752-84-7
1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; bromine / DMF (N,N-dimethyl-formamide) / 1 h

2: methanol / 20 h / 40 °C

With pyridine; bromine; In methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

: 666752-51-8
6-{[(1R)-2-hydroxy-1-methylethyl]amino}-2-mercapto-4-pyrimidinol

: 666752-84-7
1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 1 h

2: pyridine; bromine / DMF (N,N-dimethyl-formamide) / 1 h

3: methanol / 20 h / 40 °C

With pyridine; sodium hydroxide; bromine; In methanol; DMF (N,N-dimethyl-formamide); ethanol; water;