4-Piperidinecarboxamide, N-[(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]- 1-phenylpropyl]-1-(2-methyl-1-oxopropyl)-

Base Information

Chemical Name:4-Piperidinecarboxamide, N-[(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]- 1-phenylpropyl]-1-(2-methyl-1-oxopropyl)-
CAS No.:667402-10-0
Molecular Formula:C35H50N4O5S
Molecular Weight:638.872
Hs Code.:

4-Piperidinecarboxamide,
N-[(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]-
1-phenylpropyl]-1-(2-methyl-1-oxopropyl)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Piperidinecarboxamide, N-[(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]- 1-phenylpropyl]-1-(2-methyl-1-oxopropyl)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Piperidinecarboxamide, N-[(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]- 1-phenylpropyl]-1-(2-methyl-1-oxopropyl)-

There total 12 articles about 4-Piperidinecarboxamide, N-[(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]- 1-phenylpropyl]-1-(2-methyl-1-oxopropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 667402-27-9
(S)-piperidine-4-carboxylic acid [3-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-amide

: 79-30-1
isobutyryl chloride

: 667402-10-0
(S)-1-isobutyryl-piperidine-4-carboxylic acid [3-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 374725-41-4
N-(1-benzyl-piperidin-4-yl)-N-ethyl-2-(4-methanesulfonyl-phenyl)-acetamide

: 667402-10-0
(S)-1-isobutyryl-piperidine-4-carboxylic acid [3-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium formate / Pd/C (30%) / ethanol / 4 h / Heating / reflux

2.1: sodium tris(acetoxy)borohydride; acetic acid / methanol; dichloromethane / 12 h / 20 °C

2.2: 0.5 h

3.1: hydrogenchloride / methanol; dichloromethane / 1 h

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.08 h / 20 °C

4.2: 18 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 18 h / 20 °C

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; Pd/C (30%); In methanol; ethanol; dichloromethane;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 667402-10-0
(S)-1-isobutyryl-piperidine-4-carboxylic acid [3-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran; methanol / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: dmap; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C

3.1: ammonium formate / Pd/C (30%) / ethanol / 4 h / Heating / reflux

4.1: sodium tris(acetoxy)borohydride; acetic acid / methanol; dichloromethane / 12 h / 20 °C

4.2: 0.5 h

5.1: hydrogenchloride / methanol; dichloromethane / 1 h

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.08 h / 20 °C

6.2: 18 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.1: triethylamine / dichloromethane / 18 h / 20 °C

With hydrogenchloride; dmap; ammonium formate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; Pd/C (30%); In tetrahydrofuran; methanol; ethanol; dichloromethane;