Carbamic acid, [(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]-1- phenylpropyl]-, 2,2,2-trichloroethyl ester, monohydrochloride

Base Information

Chemical Name:Carbamic acid, [(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]-1- phenylpropyl]-, 2,2,2-trichloroethyl ester, monohydrochloride
CAS No.:667402-23-5
Molecular Formula:C₂₈H₃₆Cl₃N₃O₅S*ClH
Molecular Weight:669.497
Hs Code.:

Carbamic acid,
[(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]-1-
phenylpropyl]-, 2,2,2-trichloroethyl ester, monohydrochloride

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]-1- phenylpropyl]-, 2,2,2-trichloroethyl ester, monohydrochloride

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Technology Process of Carbamic acid, [(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]-1- phenylpropyl]-, 2,2,2-trichloroethyl ester, monohydrochloride

There total 8 articles about Carbamic acid, [(1S)-3-[4-[ethyl[[4-(methylsulfonyl)phenyl]acetyl]amino]-1-piperidinyl]-1- phenylpropyl]-, 2,2,2-trichloroethyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374725-41-4
N-(1-benzyl-piperidin-4-yl)-N-ethyl-2-(4-methanesulfonyl-phenyl)-acetamide

: 667402-23-5
(S)-[3-(4-{ethyl-[2-(4-methanesulfonylphenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-carbamic acid 1',1',1'-trichloroethoxy ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium formate / Pd/C (30%) / ethanol / 4 h / Heating / reflux

2.1: sodium tris(acetoxy)borohydride; acetic acid / methanol; dichloromethane / 12 h / 20 °C

2.2: 0.5 h

3.1: hydrogenchloride / methanol; dichloromethane / 1 h

4.1: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; Pd/C (30%); In methanol; ethanol; dichloromethane;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 667402-23-5
(S)-[3-(4-{ethyl-[2-(4-methanesulfonylphenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-carbamic acid 1',1',1'-trichloroethoxy ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; methanol / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: dmap; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C

3.1: ammonium formate / Pd/C (30%) / ethanol / 4 h / Heating / reflux

4.1: sodium tris(acetoxy)borohydride; acetic acid / methanol; dichloromethane / 12 h / 20 °C

4.2: 0.5 h

5.1: hydrogenchloride / methanol; dichloromethane / 1 h

6.1: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; dmap; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; Pd/C (30%); In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: N-ethyl-2-(4-methanesulfonyl-phenyl)-N-piperidin-4-yl-acetamide dihydrochloride

: 667402-23-5
(S)-[3-(4-{ethyl-[2-(4-methanesulfonylphenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-carbamic acid 1',1',1'-trichloroethoxy ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C

2.1: ammonium formate / Pd/C (30%) / ethanol / 4 h / Heating / reflux

3.1: sodium tris(acetoxy)borohydride; acetic acid / methanol; dichloromethane / 12 h / 20 °C

3.2: 0.5 h

4.1: hydrogenchloride / methanol; dichloromethane / 1 h

5.1: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; dmap; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; Pd/C (30%); In methanol; ethanol; dichloromethane;