2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(4-isocyanato-1- piperidinyl)-4-methyl-1H-benzimidazol-2-yl]-

Base Information

• Chemical Name: 2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(4-isocyanato-1- piperidinyl)-4-methyl-1H-benzimidazol-2-yl]-
• CAS No.: 667402-65-5
• Molecular Formula: C27H27ClN6O3
• Molecular Weight: 519.003
• Mol file: 667402-65-5.mol

Synonyms:

Chemical Property of 2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(4-isocyanato-1- piperidinyl)-4-methyl-1H-benzimidazol-2-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(4-isocyanato-1- piperidinyl)-4-methyl-1H-benzimidazol-2-yl]-

There total 1 articles about 2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(4-isocyanato-1- piperidinyl)-4-methyl-1H-benzimidazol-2-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H29ClN6O2 (1056877-67-8) → 4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(4-isocyanato-piperidin-1-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one (667402-65-5)

Guidance literature:

With di-tert-butyl tricarbonate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 23.0%

4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(4-isocyanato-piperidin-1-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one (667402-65-5) + (S)-(+)-2-methoxypropanol (116422-39-0) → [1-(2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzoimidazol-5-yl)-piperidin-4-yl]-carbamic acid 2-methoxy-propyl ester (667402-38-2)

Guidance literature:

(S)-(+)-2-methoxypropanol; With sodium hydride; In tetrahydrofuran; for 0.0833333h;

4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(4-isocyanato-piperidin-1-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield: 17.0%

4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(4-isocyanato-piperidin-1-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one (667402-65-5) + 3-tetrahydrofuranmethanol (124391-75-9,124506-31-6,15833-61-1) → [1-(2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzoimidazol-5-yl)-piperidin-4-yl]-carbamic acid tetrahydro-furan-3-ylmethyl ester (667402-35-9)

Guidance literature:

3-tetrahydrofuranmethanol; With sodium hydride; In tetrahydrofuran; for 0.0833333h;

4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(4-isocyanato-piperidin-1-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one; In tetrahydrofuran; at 20 ℃; for 0.5h;

upstream raw materials:

C₂₆H₂₉ClN₆O₂

Downstream raw materials:

[1-(2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzoimidazol-5-yl)-piperidin-4-yl]-carbamic acid 2-methoxy-propyl ester

[1-(2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzoimidazol-5-yl)-piperidin-4-yl]-carbamic acid tetrahydro-furan-3-ylmethyl ester