4-Chloro-2-(3-methoxyphenyl)-6-methylpyrimidine

Base Information

Chemical Name:4-Chloro-2-(3-methoxyphenyl)-6-methylpyrimidine
CAS No.:66744-02-3
Molecular Formula:C₁₂H₁₁ClN₂O
Molecular Weight:234.685
Hs Code.:2933599090
DSSTox Substance ID:DTXSID10656173
Wikidata:Q82570702

Synonyms:4-CHLORO-2-(3-METHOXYPHENYL)-6-METHYLPYRIMIDINE;DTXSID10656173;66744-02-3

Suppliers and Price of 4-Chloro-2-(3-methoxyphenyl)-6-methylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-Chloro-2-(3-methoxyphenyl)-6-methylpyrimidine

Chemical Property:

Melting Point:68-70 °C
Boiling Point:281.0±32.0 °C(Predicted)
PKA:0.24±0.50(Predicted)
PSA：35.01000
Density:1.213±0.06 g/cm3(Predicted)
LogP:3.11400
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:234.0559907
Heavy Atom Count:16
Complexity:227

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NC(=N1)C2=CC(=CC=C2)OC)Cl

Technology Process of 4-Chloro-2-(3-methoxyphenyl)-6-methylpyrimidine

There total 4 articles about 4-Chloro-2-(3-methoxyphenyl)-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858269-27-9
2-(3-methoxy-phenyl)-6-methyl-3H-pyrimidin-4-one

: 66744-02-3
4-chloro-2-(3-methoxy-phenyl)-6-methyl-pyrimidine

Guidance literature:: With trichlorophosphate;
DOI:10.1039/jr9460000362

Reference yield:

: 1527-89-5
3-methoxybenzonitrile

: 66744-02-3
4-chloro-2-(3-methoxy-phenyl)-6-methyl-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen chloride; chloroform; ethanol / Erwaermen des nach 2 Tagen isolierten 3-Methoxy-benzimidsaeure-aethylester-hydrochlorids mit aethanol. Ammoniak

2: aq. NaOH solution

3: POCl₃

With hydrogenchloride; sodium hydroxide; ethanol; chloroform; trichlorophosphate;
DOI:10.1039/jr9460000362

Reference yield:

: 26113-44-0
3-methoxybenzene-1-carboximidamide hydrogenchloride

: 66744-02-3
4-chloro-2-(3-methoxy-phenyl)-6-methyl-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH solution

2: POCl₃

With sodium hydroxide; trichlorophosphate;
DOI:10.1039/jr9460000362