2,3,3a,5,10,10a-Hexahydro-3a-ethyl-2-methyl-4H-furo(2,3-b)(1,5)benzodiazepin-4-one

Base Information

• Chemical Name: 2,3,3a,5,10,10a-Hexahydro-3a-ethyl-2-methyl-4H-furo(2,3-b)(1,5)benzodiazepin-4-one
• CAS No.: 77414-12-1
• Molecular Formula: C₁₄H₁₈N₂O₂
• Molecular Weight: 246.309
• DSSTox Substance ID: DTXSID10998626
• Mol file: 77414-12-1.mol

Synonyms:BRN 5956374;77414-12-1;2,3,3a,5,10,10a-Hexahydro-3a-ethyl-2-methyl-4H-furo(2,3-b)(1,5)benzodiazepin-4-one;4H-Furo(2,3-b)(1,5)benzodiazepin-4-one, 2,3,3a,5,10,10a-hexahydro-3a-ethyl-2-methyl-;DTXSID10998626;LS-70664;3a-Ethyl-2-methyl-3,3a,10,10a-tetrahydro-2H-furo[2,3-b][1,5]benzodiazepin-4-ol

Chemical Property of 2,3,3a,5,10,10a-Hexahydro-3a-ethyl-2-methyl-4H-furo(2,3-b)(1,5)benzodiazepin-4-one

Chemical Property:

• Vapor Pressure: 9.27E-08mmHg at 25°C
• Boiling Point: 434.7°C at 760 mmHg
• Flash Point: 216.7°C
• Density: 1.118g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 246.136827821
• Heavy Atom Count: 18
• Complexity: 347

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC12CC(OC1NC3=CC=CC=C3NC2=O)C

Technology Process of 2,3,3a,5,10,10a-Hexahydro-3a-ethyl-2-methyl-4H-furo(2,3-b)(1,5)benzodiazepin-4-one

There total 2 articles about 2,3,3a,5,10,10a-Hexahydro-3a-ethyl-2-methyl-4H-furo(2,3-b)(1,5)benzodiazepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

10a-Ethyl-2-methyl-1,2,9,10a-tetrahydro-3-oxa-4,9-diaza-benzo[f]azulen-10-one (77420-13-4) → 10a-Ethyl-2-methyl-1,2,3a,4,9,10a-hexahydro-3-oxa-4,9-diaza-benzo[f]azulen-10-one (77414-12-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h; Ambient temperature;

Reference yield:

3-allyl-3-ethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione (54871-36-2) → 10a-Ethyl-2-methyl-1,2,3a,4,9,10a-hexahydro-3-oxa-4,9-diaza-benzo[f]azulen-10-one (77414-12-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 100percent H₂SO₄ / 0.5 h / Ambient temperature

2: 81 percent / NaBH₄ / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; In methanol;

upstream raw materials:

10a-Ethyl-2-methyl-1,2,9,10a-tetrahydro-3-oxa-4,9-diaza-benzo[f]azulen-10-one

3-allyl-3-ethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione