6-BroMo-1-Methylisatin

Base Information

• Chemical Name: 6-BroMo-1-Methylisatin
• CAS No.: 667463-64-1
• Molecular Formula: C9H6BrNO2
• Molecular Weight: 240.056
• Hs Code.: 2933990090
• Mol file: 667463-64-1.mol

Synonyms:6-bromo-1-methyl-1H-indole-2,3-dione;6-Brom-N-methylisatin;1-methyl-6-bromolndoline-2,3-dione;5-bromo-1-methylisatin;6-BROMO-1-METHYLINDOLINE-2,3-DIONE;6-bromo-N-methylisatin;

Chemical Property of 6-BroMo-1-Methylisatin

Chemical Property:

• PSA: 37.38000
• LogP: 1.67320
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-1-methylindoline-2,3-dione 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-1-Methylisatin

There total 2 articles about 6-BroMo-1-Methylisatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.2%

C9H10BrNO2 → 4-bromo-1-methylindoline-2,3-dione (884855-67-8) + 6-bromo-N-methylisatin (667463-64-1)

Guidance literature:

With ruthenium trichloride; dimethyl sulfoxide; at 100 ℃; for 5h; Overall yield = 80 %;

DOI:10.1016/j.tet.2016.04.041

Reference yield:

C9H8BrNO2 → 4-bromo-1-methylindoline-2,3-dione (884855-67-8) + 6-bromo-N-methylisatin (667463-64-1)

Guidance literature:

With palladium dichloride; In dimethyl sulfoxide; at 100 ℃; for 3h; Overall yield = 87 %;

DOI:10.1039/c5ra23837d

Reference yield: 98.0%

(E)-[3-(4-methoxyphenyl)allyl]boronic acid + 6-bromo-N-methylisatin (667463-64-1) → (S)-6-bromo-3-hydroxy-1-methyl-3-[(R)-1-(4-methoxyphenyl)allyl]indolin-2-one

Guidance literature:

6-bromo-N-methylisatin; With C₄₂H₅₄N₄O₄; lutetium triflate; In tetrahydrofuran; at -50 - 35 ℃; for 0.5h; Molecular sieve;

(E)-[3-(4-methoxyphenyl)allyl]boronic acid; In tetrahydrofuran; at -50 ℃; for 30h; enantioselective reaction; Molecular sieve;

DOI:10.1021/acs.orglett.1c03101

Downstream raw materials:

MeBIO

6-bromo-1-methylindolin-2-one

5'-bromo-1'-methyl-1,3-diphenyl-1H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',5(10H)-dione

C₂₆H₂₁BrN₄O₃