Glycine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester

Base Information

• Chemical Name: Glycine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester
• CAS No.: 66789-38-6
• Molecular Formula: C25H30N2O7
• Molecular Weight: 470.522
• Mol file: 66789-38-6.mol

Synonyms:

Chemical Property of Glycine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester

There total 2 articles about Glycine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92%

Gly-OBz (1738-68-7) + ZAsp(OtBu)OSu → Z-Asp(OBut)-Gly-OBzl (66789-38-6)

Guidance literature:

In N,N-dimethyl-formamide; for 4h;

DOI:10.1007/BF00630258

Reference yield: 76%

Gly-OBz (1738-68-7) + Z-D(tBu)-OH (5545-52-8) → Z-Asp(OBut)-Gly-OBzl (66789-38-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 0 deg C, 2 h, then room temperature, 24 h;

Reference yield:

Z-Asp(OBut)-Gly-OBzl (66789-38-6) → (S)-3-Amino-N-benzyloxycarbonylmethyl-succinamic acid tert-butyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1007/BF00630258

upstream raw materials:

Gly-OBz

Z-D(tBu)-OH

Downstream raw materials:

Z-D-Ala-Asp(OBu^t)-Gly-OH

Boc-Tyr-D-Ala-Asp(OBu^t)-Gly-OH

Boc-Tyr-D-Ala-Asp(OBu^t)-Gly-Tyr-Pro-Ser-NH₂

ZThrAsp(OtBu)GlyOH

Refernces

• 1、 Marastoni,Salvadori,Balboni,Borea,Tomatis. "Synthesis and activity of dermorphin-growth hormone releasing factor hybrid peptides". . p. 639 - 641. Retrieved 2007/10/02.