3-Piperidinecarboxylic acid, 1-[2-[(2,5-difluorophenyl)thio]ethyl]-4-[3-(3-fluoro-6-methoxy-4-quinolinyl) -3-oxopropyl]-, methyl ester, (3R,4R)-

Base Information

• Chemical Name: 3-Piperidinecarboxylic acid, 1-[2-[(2,5-difluorophenyl)thio]ethyl]-4-[3-(3-fluoro-6-methoxy-4-quinolinyl) -3-oxopropyl]-, methyl ester, (3R,4R)-
• CAS No.: 668463-29-4
• Molecular Formula: C28H29F3N2O4S
• Molecular Weight: 546.61

Synonyms:

Chemical Property of 3-Piperidinecarboxylic acid, 1-[2-[(2,5-difluorophenyl)thio]ethyl]-4-[3-(3-fluoro-6-methoxy-4-quinolinyl) -3-oxopropyl]-, methyl ester, (3R,4R)-

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-Piperidinecarboxylic acid, 1-[2-[(2,5-difluorophenyl)thio]ethyl]-4-[3-(3-fluoro-6-methoxy-4-quinolinyl) -3-oxopropyl]-, methyl ester, (3R,4R)-

There total 1 articles about 3-Piperidinecarboxylic acid, 1-[2-[(2,5-difluorophenyl)thio]ethyl]-4-[3-(3-fluoro-6-methoxy-4-quinolinyl) -3-oxopropyl]-, methyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-bromoethylthio)-1,4-difluorobenzene (426842-92-4) + methyl (3R,4R)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-3-oxopropyl]piperidine-3-carboxylate (668463-21-6) → methyl (3R,4R)-4-[3-oxo-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenylsulfanyl)ethyl]piperidine-3-carboxylate (668463-29-4)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; at 75 ℃; for 20h;

Reference yield:

methyl (3R,4R)-4-[3-oxo-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenylsulfanyl)ethyl]piperidine-3-carboxylate (668463-29-4) → (3R,4R)-4-[3-Oxo-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenylsulfanyl)ethyl]piperidine-3-carboxylic acid (668463-28-3)

Guidance literature:

With hydrogenchloride; water; at 80 ℃; for 5h;

upstream raw materials:

2-(2-bromoethylthio)-1,4-difluorobenzene

methyl (3R,4R)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)-3-oxopropyl]piperidine-3-carboxylate

Downstream raw materials:

(3R,4R)-4-[3-Oxo-3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]-1-[2-(2,5-difluorophenylsulfanyl)ethyl]piperidine-3-carboxylic acid

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