3-Hydroxy-1-methyl-3-(2-oxopropyl)-2-indolinone acetate (ester) 3-oxime

Base Information

• Chemical Name: 3-Hydroxy-1-methyl-3-(2-oxopropyl)-2-indolinone acetate (ester) 3-oxime
• CAS No.: 107864-74-4
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.292
• Mol file: 107864-74-4.mol

Synonyms:BRN 5593505;2-INDOLINONE, 3-ACETONYL-3-HYDROXY-1-METHYL-, ACETATE (ester), 3-OXIME;3-Hydroxy-1-methyl-3-(2-oxopropyl)-2-indolinone acetate (ester) 3-oxime;107864-74-4;LS-83486

Chemical Property of 3-Hydroxy-1-methyl-3-(2-oxopropyl)-2-indolinone acetate (ester) 3-oxime

Chemical Property:

• Vapor Pressure: 2.53E-11mmHg at 25°C
• Boiling Point: 512.4°Cat760mmHg
• Flash Point: 263.7°C
• Density: 1.26g/cm³
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 276.11100700
• Heavy Atom Count: 20
• Complexity: 449

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NO)CC1(C2=CC=CC=C2N(C1=O)C)OC(=O)C
• Isomeric SMILES: C/C(=N/O)/CC1(C2=CC=CC=C2N(C1=O)C)OC(=O)C

Technology Process of 3-Hydroxy-1-methyl-3-(2-oxopropyl)-2-indolinone acetate (ester) 3-oxime

There total 2 articles about 3-Hydroxy-1-methyl-3-(2-oxopropyl)-2-indolinone acetate (ester) 3-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.4%

1-Methyl-3-acetoxy-3-acetonyloxindole (107864-78-8) → 1-Methyl-3-acetoxy-3-acetonyloxindole oxime (107864-74-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 2h; Heating;

DOI:10.1007/BF00765104

Reference yield:

3-hydroxy-1-methyl-3-(2'-oxopropyl)indolin-2-one (76325-64-9) → 1-Methyl-3-acetoxy-3-acetonyloxindole oxime (107864-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 64.7 percent / pyridine / 24 h / 20 - 22 °C

2: 78.4 percent / NH₂OH*HCl, AcONa / aq. ethanol / 2 h / Heating

With pyridine; hydroxylamine hydrochloride; sodium acetate; In ethanol;

DOI:10.1007/BF00765104

upstream raw materials:

1-Methyl-3-acetoxy-3-acetonyloxindole

3-hydroxy-1-methyl-3-(2'-oxopropyl)indolin-2-one