Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-D-alanyl-2-(3-chloro-4-hydroxy phenyl)-, (2S)-

Base Information

Chemical Name:Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-D-alanyl-2-(3-chloro-4-hydroxy phenyl)-, (2S)-
CAS No.:668985-55-5
Molecular Formula:C22H32ClN3O7
Molecular Weight:485.965
Hs Code.:

Synonyms:

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Chemical Property of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-D-alanyl-2-(3-chloro-4-hydroxy phenyl)-, (2S)-

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Technology Process of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-D-alanyl-2-(3-chloro-4-hydroxy phenyl)-, (2S)-

There total 4 articles about Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-D-alanyl-2-(3-chloro-4-hydroxy phenyl)-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 668985-54-4
Boc-L-Leu-D-Ala-L-Chp-OBn

: 668985-55-5
Boc-L-Leu-D-Ala-L-Chp-OH

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 0.5h; under 760 Torr;
DOI:10.1021/ja039671y

Reference yield:

: 374116-21-9
BOC-L-Leu-D-Ala-OH

: 668985-55-5
Boc-L-Leu-D-Ala-L-Chp-OH

Guidance literature:: Multi-step reaction with 2 steps

1: 1.97 g / HOAt; NaHCO₃; EDCI / dimethylformamide; CH₂Cl₂ / 14 h / 0 °C

2: 100 percent / H₂ / Pd/C / methanol / 0.5 h / 25 °C / 760 Torr

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja039671y

Reference yield:

: 436849-00-2
N-tert-butoxycarbonyl-(S)-3-chloro-4-hydroxyphenylglycine benzyl ester

: 668985-55-5
Boc-L-Leu-D-Ala-L-Chp-OH

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / ethyl acetate / 1 h / 25 °C

2: 1.97 g / HOAt; NaHCO₃; EDCI / dimethylformamide; CH₂Cl₂ / 14 h / 0 °C

3: 100 percent / H₂ / Pd/C / methanol / 0.5 h / 25 °C / 760 Torr

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja039671y